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styk1b serine/threonine/tyrosine kinase 1b [ Danio rerio (zebrafish) ]

Gene ID: 324714, updated on 2-Nov-2024

Summary

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Official Symbol
styk1bprovided by ZNC
Official Full Name
serine/threonine/tyrosine kinase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3435
See related
Ensembl:ENSDARG00000041947 AllianceGenome:ZFIN:ZDB-GENE-030131-3435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
styk1; styk1c; wu:fc39b09; wu:fe11d05
Summary
Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human STYK1 (serine/threonine/tyrosine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See styk1b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31968368..31976265, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32014338..32022235, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108179621 Neighboring gene polyhomeotic homolog 1 Neighboring gene glutathione S-transferase kappa 1 Neighboring gene glutathione S-transferase kappa 4 Neighboring gene membrane bound O-acyltransferase domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I. Zhou C, et al. Autophagy, 2020 Oct. PMID 31696776, Free PMC Article
  2. Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. Wang YF, et al. Int J Biol Sci, 2015. PMID 26327813, Free PMC Article
  3. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase STYK1b
Names
serine/threonine/tyrosine kinase 1
NP_001292494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305565.1 → NP_001292494.1  tyrosine-protein kinase STYK1b

    Status: VALIDATED

    Source sequence(s)
    CR854927, EH444855, EH470731
    UniProtKB/TrEMBL
    A0A8M1P7D1, E9QCV8
    Related
    ENSDARP00000112925.1, ENSDART00000139664.2
    Conserved Domains (2) summary
    pfam07714
    Location:164 → 408
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:164 → 409
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    31968368..31976265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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