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hmga2 high mobility group AT-hook 2 [ Danio rerio (zebrafish) ]

Gene ID: 324428, updated on 2-Nov-2024

Summary

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Official Symbol
hmga2provided by ZNC
Official Full Name
high mobility group AT-hook 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3148
See related
Ensembl:ENSDARG00000069912 AllianceGenome:ZFIN:ZDB-GENE-030131-3148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77719; wu:fc27f12; wu:fc28f02; wu:fc57d12
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including blood vessel; head; nervous system; pectoral fin bud; and pronephric duct. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See hmga2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12819278..12862087, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12820429..12863132, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene beta-2-microglobulin Neighboring gene uncharacterized LOC103910419 Neighboring gene methionine sulfoxide reductase B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins. Shin YJ, et al. Sci Rep, 2015 Sep 16. PMID 26373678, Free PMC Article
  2. Next-generation sequencing identifies novel genes with rare variants in total anomalous pulmonary venous connection. Shi X, et al. EBioMedicine, 2018 Dec. PMID 30448225, Free PMC Article
  3. The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Moussavi Nik SH, et al. Exp Cell Res, 2011 Jul 1. PMID 21530505
  4. The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration. Sinclair JW, et al. NPJ Regen Med, 2021 Sep 13. PMID 34518542, Free PMC Article
  5. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. Stockhammer OW, et al. J Immunol, 2009 May 1. PMID 19380811

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
high mobility group protein HMGI-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212680.2 → NP_997845.1  high mobility group protein HMGI-C

    See identical proteins and their annotated locations for NP_997845.1

    Status: VALIDATED

    Source sequence(s)
    BX119963, BX901955
    UniProtKB/TrEMBL
    A0A8M1PLC1, Q6P038
    Related
    ENSDARP00000074985.6, ENSDART00000080536.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    12819278..12862087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099421.2: Suppressed sequence

    Description
    NM_001099421.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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