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Muc12Ea Mucin 12Ea [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32384, updated on 11-Sep-2024

Summary

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Official Symbol
Muc12Eaprovided by FlyBase
Official Full Name
Mucin 12Eaprovided by FlyBase
Primary source
FLYBASE:FBgn0052602
Locus tag
Dmel_CG32602
See related
AllianceGenome:FB:FBgn0052602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32602; CG5228; Dmel\CG32602
Summary
Predicted to be an extracellular matrix structural constituent. Involved in chorion-containing eggshell formation. Predicted to be located in extracellular matrix. Is expressed in embryonic/larval salivary gland and organism. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Muc12Ea in Genome Data Viewer
Location:
12E7-12E7; 1-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14277735..14288161)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14171768..14182194)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tyrosine aminotransferase Neighboring gene uncharacterized protein Neighboring gene narrow abdomen Neighboring gene long non-coding RNA:CR44963 Neighboring gene uncharacterized protein Neighboring gene Nascent-associated complex beta-subunit-like, testis 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila eggshell production: identification of new genes and coordination by Pxt. Tootle TL, et al. PLoS One, 2011. PMID 21637834, Free PMC Article
  2. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article
  3. A potential role for Drosophila mucins in development and physiology. Syed ZA, et al. PLoS One, 2008 Aug 22. PMID 18725942, Free PMC Article
  4. A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster. López Y, et al. PLoS One, 2014. PMID 25153327, Free PMC Article
  5. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Kong EC, et al. Alcohol Clin Exp Res, 2010 Feb. PMID 19951294, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables extracellular matrix structural constituent ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chorion-containing eggshell formation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in egg chorion IC
Inferred by Curator
more info
 PubMed 
located_in extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
mucin 12Ea
Names
CG32602-PC
Muc12Ea-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14277735..14288161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382061.1 → NP_001368944.1  mucin 12Ea [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR52
    Conserved Domains (1) summary
    PHA03247
    Location:2110 → 2706
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR52 Q8IR52

Gene LinkOut

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