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ewsr1a EWS RNA-binding protein 1a [ Danio rerio (zebrafish) ]

Gene ID: 323597, updated on 17-Sep-2024

Summary

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Official Symbol
ewsr1aprovided by ZNC
Official Full Name
EWS RNA-binding protein 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2317
See related
Ensembl:ENSDARG00000020258 AllianceGenome:ZFIN:ZDB-GENE-030131-2317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EWSR1; fc04c01; wu:fc04c01
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including mitotic spindle midzone assembly; regulation of chondrocyte hypertrophy; and regulation of mitotic nuclear division. Predicted to be active in nucleus. Is expressed in fin bud; nervous system; and trunk. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ewsr1a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7975585..7988412, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (8016885..8029728, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E4 Neighboring gene oxysterol binding protein 2a Neighboring gene ATPase H+ transporting V0 subunit a2a Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish. Park H, et al. Sci Rep, 2016 Aug 25. PMID 27557633, Free PMC Article
  2. Reversible and Irreversible Aggregation of Proteins from the FET Family: Influence of Repeats in Protein Chain on Its Aggregation Capacity. Galzitskaya OV. Curr Protein Pept Sci, 2016. PMID 26100283
  3. Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines. Embree LJ, et al. Cancer Res, 2009 May 15. PMID 19417137, Free PMC Article
  4. Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. Azuma M, et al. PLoS One, 2007 Oct 3. PMID 17912356, Free PMC Article
  5. Characterization of genetic loss-of-function of Fus in zebrafish. Lebedeva S, et al. RNA Biol, 2017 Jan 2. PMID 27898262, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of the EWS gene modulates Sox9 gene expression essential for chondrocyte differentiation.
    Title: Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish.
  2. Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
    Title: Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
  3. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
    Title: Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of chondrocyte hypertrophy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EWS RNA-binding protein 1a
Names
Ewing sarcoma breakpoint region 1
Ewing sarcoma breakpoint region 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115138.2 → NP_001108610.1  EWS RNA-binding protein 1a

    See identical proteins and their annotated locations for NP_001108610.1

    Status: VALIDATED

    Source sequence(s)
    BC068397, CN835703, DT075886, EH467947, FP131351, FP154885
    UniProtKB/TrEMBL
    A0A0B4J1A5, A0A8N1TRE3, Q6NUX1
    Related
    ENSDARP00000024102.7, ENSDART00000024282.9
    Conserved Domains (4) summary
    COG0724
    Location:329 → 431
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12533
    Location:346 → 429
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:499 → 520
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:495 → 525
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    7975585..7988412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479109.2 → XP_021334784.1  EWS RNA-binding protein 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M9QBU8, Q6NUX1
    Conserved Domains (3) summary
    cd12533
    Location:317 → 400
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    sd00025
    Location:470 → 491
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:466 → 496
    zf-RanBP; Zn-finger in Ran binding protein and others

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394766.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    140953..153780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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