Clic Chloride intracellular channel [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Clicprovided by FlyBase
Official Full Name: Chloride intracellular channelprovided by FlyBase
Primary source: FLYBASE:FBgn0030529
Locus tag: Dmel_CG10997
See related: AllianceGenome:FB:FBgn0030529
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10997; clic; CLIC; DCLIC; DmCLIC; Dmel\CG10997; l(1)G0053; l(1)G0472
Summary: Enables calcium ion binding activity; chloride channel activity; and lipid binding activity. Involved in chloride transport; negative gravitaxis; and response to alcohol. Located in mitochondrion. Is expressed in several structures, including adult head; gut section; and nurse cell. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome and autosomal recessive nonsyndromic deafness 103. Orthologous to several human genes including CLIC2 (chloride intracellular channel 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13812971..13822307, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13707004..13716340, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

distinguishing features of Clic structure determined from crystal structure are described
Title: Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative gravitaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to alcohol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed

NP_001259537.2

NP_572928.1

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The following sections contain reference sequences that belong to a specific genome build. Explain