U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rdgB retinal degeneration B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32340, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
rdgBprovided by FlyBase
Official Full Name
retinal degeneration Bprovided by FlyBase
Primary source
FLYBASE:FBgn0003218
Locus tag
Dmel_CG11111
See related
AllianceGenome:FB:FBgn0003218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11111; Dmel\CG11111; DrdgB; DrdgBalpha; hypoF; ota1; rdbB(ota1); RdgB; RDGB; rdgBalpha; RdgBalpha; RDGBalpha; x36
Summary
Enables phospholipid binding activity and phospholipid transporter activity. Involved in several processes, including deactivation of rhodopsin mediated signaling; rhodopsin mediated signaling pathway; and sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval central nervous system; and gonad. Human ortholog(s) of this gene implicated in cone-rod dystrophy 5. Orthologous to several human genes including PITPNM2 (phosphatidylinositol transfer protein membrane associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rdgB in Genome Data Viewer
Location:
12C1-12C4; 1-46 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13762752..13779488)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13656785..13673521)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rtc1 Neighboring gene Yolk protein 3 Neighboring gene Cathepsin B Neighboring gene amaretto

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. rdgB knockdown in neurons reduced nocturnal sleep in Drosophila melanogaster. Kobayashi R, et al. Biochem Biophys Res Commun, 2023 Feb 5. PMID 36586155
  2. Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites. Basak B, et al. Biol Open, 2021 Mar 18. PMID 33597200, Free PMC Article
  3. The rdgB gene of Drosophila: a link between vision and olfaction. Woodard C, et al. J Neurogenet, 2007 Oct-Dec. PMID 18161590
  4. The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Lev S. Exp Cell Res, 2004 Jul 1. PMID 15194420
  5. The contribution of lipids and lipid metabolism to cellular functions of the Golgi complex. Fang M, et al. Biochim Biophys Acta, 1998 Aug 14. PMID 9714753

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. membrane contact site localization of RDGBalpha depends on the interaction of its FFAT motif with dVAP-A
    Title: RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions.
  2. Thus RDGB couples the turnover of both PtdIns and PtdOH, key lipid intermediates during G-protein-coupled PtdIns(4,5)P2 turnover.
    Title: RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction.
  3. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.
    Title: Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidic acid transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol transfer activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables phospholipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled opsin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of opsin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of opsin-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in phototransduction, visible light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in subrhabdomeral cisterna NAS
Non-traceable Author Statement
more info
 PubMed 
located_in subrhabdomeral cisterna TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
retinal degeneration B
Names
CG11111-PA
CG11111-PB
CG11111-PC
CG11111-PD
CG11111-PE
CG11111-PF
CG11111-PG
CG11111-PH
CG11111-PI
CG11111-PJ
CG11111-PK
rdgB-PA
rdgB-PB
rdgB-PC
rdgB-PD
rdgB-PE
rdgB-PF
rdgB-PG
rdgB-PH
rdgB-PI
rdgB-PJ
rdgB-PK
receptor degeneration B
receptor-degeneration-II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13762752..13779488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272605.2 → NP_001259534.1  retinal degeneration B, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259534.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJM8
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1072 → 1203
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:746 → 924
    DDHD; DDHD domain

  2. NM_001014741.3 → NP_001014741.1  retinal degeneration B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014741.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4E8, O02434, P43125, Q6NP01, Q961R2, Q9VY88
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain

  3. NM_167382.3 → NP_727733.1  retinal degeneration B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727733.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4E8, O02434, P43125, Q6NP01, Q961R2, Q9VY88
    Related
    FBpp0073653
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain

  4. NM_001014740.2 → NP_001014740.1  retinal degeneration B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014740.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4E8, O02434, P43125, Q6NP01, Q961R2, Q9VY88
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain

  5. NM_001169280.3 → NP_001162751.1  retinal degeneration B, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162751.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJK6
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1072 → 1203
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:746 → 924
    DDHD; DDHD domain

  6. NM_001169278.3 → NP_001162749.1  retinal degeneration B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJK7
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain

  7. NM_001169279.3 → NP_001162750.1  retinal degeneration B, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162750.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJK8
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1046 → 1177
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 898
    DDHD; DDHD domain

  8. NM_001169277.2 → NP_001162748.1  retinal degeneration B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJK9
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain

  9. NM_001272606.1 → NP_001259535.1  retinal degeneration B, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEJ5
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1072 → 1203
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:746 → 924
    DDHD; DDHD domain

  10. NM_001298300.1 → NP_001285229.1  retinal degeneration B, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285229.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JF93
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain

  11. NM_078594.3 → NP_511149.2  retinal degeneration B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511149.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJK7
    Related
    FBpp0073654
    Conserved Domains (3) summary
    cd08889
    Location:1 → 268
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1059 → 1190
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:733 → 911
    DDHD; DDHD domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJK6 E1JJK6
E1JJK7 E1JJK7
E1JJK8 E1JJK8
E1JJK9 E1JJK9
M9PEJ5 M9PEJ5
M9PJM8 M9PJM8
P43125.2 P43125
X2JF93 X2JF93

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous