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Muc11A Mucin 11A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32174, updated on 2-Nov-2024

Summary

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Official Symbol
Muc11Aprovided by FlyBase
Official Full Name
Mucin 11Aprovided by FlyBase
Primary source
FLYBASE:FBgn0052656
Locus tag
Dmel_CG32656
See related
AllianceGenome:FB:FBgn0052656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2779; CG32656; Dmel\CG32656
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; embryonic/larval fat body; and embryonic/larval proventriculus. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Muc11A in Genome Data Viewer
Location:
11A2-11A3; 1-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12059795..12065144)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11953828..11959177)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43960 Neighboring gene Cytochrome P450 318a1 Neighboring gene long non-coding RNA:CR43961 Neighboring gene Tenascin accessory Neighboring gene Uch-L5-related Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. May C, et al. J Biol Chem, 2020 Aug 28. PMID 32669364, Free PMC Article
  2. Induced transcription results in local changes in chromatin structure, replication timing, and DNA polytenization in a site of intercalary heterochromatin. Koryakov DE, et al. Chromosoma, 2012 Dec. PMID 23015267
  3. A potential role for Drosophila mucins in development and physiology. Syed ZA, et al. PLoS One, 2008 Aug 22. PMID 18725942, Free PMC Article
  4. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
  5. Genomic variation in natural populations of Drosophila melanogaster. Langley CH, et al. Genetics, 2012 Oct. PMID 22673804, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mucin 11A
Names
CG32656-PB
Muc11A-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12059795..12065144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298221.1 → NP_001285150.1  mucin 11A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285150.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JBD0
    Conserved Domains (2) summary
    PRK07764
    Location:696 → 1109
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01607
    Location:1495 → 1547
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JXX2 Q7JXX2
X2JBD0 X2JBD0

Gene LinkOut

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