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Drak Death-associated protein kinase related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32097, updated on 18-Sep-2024

Summary

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Official Symbol
Drakprovided by FlyBase
Official Full Name
Death-associated protein kinase relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0052666
Locus tag
Dmel_CG32666
See related
AllianceGenome:FB:FBgn0052666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11713; CG1760; CG32666; Dmel\CG32666; drak; DRak; EP(X)1452; EP1452
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; and protein phosphorylation. Predicted to be active in nucleus. Is expressed in haltere disc; organism; ventral thoracic disc; and wing disc. Orthologous to human STK17A (serine/threonine kinase 17a) and STK17B (serine/threonine kinase 17b). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Drak in Genome Data Viewer
Location:
10C1-10C5; 1-35 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11493135..11555045)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11387168..11449078)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44556 Neighboring gene Spase 25-subunit Neighboring gene uncharacterized protein Neighboring gene mir-2492 stem loop Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue. Aranjuez G, et al. Mol Biol Cell, 2016 Jun 15. PMID 27122602, Free PMC Article
  2. Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. Robertson F, et al. Development, 2012 Sep. PMID 22874916, Free PMC Article
  3. Drak Is Required for Actomyosin Organization During Drosophila Cellularization. Chougule AB, et al. G3 (Bethesda), 2016 Apr 7. PMID 26818071, Free PMC Article
  4. Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. Champagne MB, et al. J Mol Biol, 2000 Jul 21. PMID 10891286
  5. Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Neubueser D, et al. Mol Biol Cell, 2010 Aug 15. PMID 20573980, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
    Title: Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
  2. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
    Title: Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in morphogenesis of an epithelium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Death-associated protein kinase related
Names
CG32666-PC
CG32666-PD
CG32666-PE
Drak-PC
Drak-PD
Drak-PE
NP_001162723.1
NP_001162724.1
NP_996411.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11493135..11555045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169253.2 → NP_001162724.1  Death-associated protein kinase related, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJH9, Q0KHT7, Q86P19
    Conserved Domains (3) summary
    PHA03255
    Location:379 → 554
    PHA03255; BDLF3; Provisional
    smart00220
    Location:45 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14106
    Location:28 → 295
    STKc_DRAK; Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase

  2. NM_001169252.2 → NP_001162723.1  Death-associated protein kinase related, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJH9, Q0KHT7, Q86P19
    Conserved Domains (3) summary
    PHA03255
    Location:379 → 554
    PHA03255; BDLF3; Provisional
    smart00220
    Location:45 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14106
    Location:28 → 295
    STKc_DRAK; Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase

  3. NM_206688.2 → NP_996411.2  Death-associated protein kinase related, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996411.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJH9, Q0KHT7, Q86P19
    Conserved Domains (3) summary
    PHA03255
    Location:379 → 554
    PHA03255; BDLF3; Provisional
    smart00220
    Location:45 → 295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14106
    Location:28 → 295
    STKc_DRAK; Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KHT7.2 Q0KHT7

Gene LinkOut

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