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LPCAT Lysophosphatidylcholine acyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31899, updated on 11-Sep-2024

Summary

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Official Symbol
LPCATprovided by FlyBase
Official Full Name
Lysophosphatidylcholine acyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0052699
Locus tag
Dmel_CG32699
See related
AllianceGenome:FB:FBgn0052699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15318; CG18535; CG2996; CG32699; CT7882; Dmel\CG32699; LPCAT1/2; tok-like
Summary
Enables lysophospholipid acyltransferase activity. Involved in lipid modification. Located in lipid droplet. Is expressed in adult head. Orthologous to several human genes including LPCAT1 (lysophosphatidylcholine acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See LPCAT in Genome Data Viewer
Location:
8E10-8E10; 1-28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9571537..9579987, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9465570..9474020, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42767 Neighboring gene Cubilin Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45540 Neighboring gene long non-coding RNA:CR45541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage. Moessinger C, et al. BMC Cell Biol, 2014 Dec 10. PMID 25491198, Free PMC Article
  2. ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration. Sunderhaus ER, et al. Neurobiol Dis, 2019 Oct. PMID 31233884, Free PMC Article
  3. Drosophila oocyte proteome composition covaries with female mating status. McDonough-Goldstein CE, et al. Sci Rep, 2021 Feb 4. PMID 33542461, Free PMC Article
  4. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article
  5. RNA editing in Drosophila melanogaster: New targets and functional consequences. Stapleton M, et al. RNA, 2006 Nov. PMID 17018572, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipid acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysophosphatidylcholine acyltransferase
Names
CG32699-PB
LPCAT-PB
Lyso-PA acyltransferase
NP_001036265.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9571537..9579987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042800.3 → NP_001036265.1  lysophosphatidylcholine acyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHU5, Q86NX4, Q95SE4, Q9W331
    Conserved Domains (3) summary
    cd07991
    Location:126 → 338
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:87 → 265
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam13833
    Location:455 → 507
    EF-hand_8; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KHU5.1 Q0KHU5

Gene LinkOut

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