HNRNPC heterogeneous nuclear ribonucleoprotein C [Homo sapiens (human)] - Gene

Summary

Official Symbol: HNRNPCprovided by HGNC
Official Full Name: heterogeneous nuclear ribonucleoprotein Cprovided by HGNC
Primary source: HGNC:HGNC:5035
See related: Ensembl:ENSG00000092199 MIM:164020; AllianceGenome:HGNC:5035
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C1; C2; HNRNP; HNRPC; MRD74; SNRPC
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 82.0), bone marrow (RPKM 78.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (21209147..21269442, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (15406559..15466855, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (21677306..21737601, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1.
Title: HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1.
The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway.
Title: The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway.
Identification of RNA-binding protein hnRNP C targeting the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.
Title: Identification of RNA-binding protein hnRNP C targeting the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.
Title: DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus.
N6-Methyladenosine reader HNRNPC-mediated downregulation of circITCH prevents miR-224-3p sequestering and contributes to tumorigenesis in nasopharyngeal carcinoma.
Title: N6-Methyladenosine reader HNRNPC-mediated downregulation of circITCH prevents miR-224-3p sequestering and contributes to tumorigenesis in nasopharyngeal carcinoma.
HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner.
Title: HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner.
HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.
Title: HNRNPC Regulates GLUT1/LDHA Pathway by Stabilizing FOXM1 mRNA to Promote the Progression and Aerobic Glycolysis of Multiple Myeloma.
Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC.
Title: Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC.
m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.
Title: m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.
HNRNPC mediated m[6]A methylation of 5-methyltetrahydrofolate-homocysteine methyltransferase and involved in the occurrence of RSA.
Title: HNRNPC mediated m(6)A methylation of 5-methyltetrahydrofolate-homocysteine methyltransferase and involved in the occurrence of RSA.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual developmental disorder, autosomal dominant 74 MedGen: C5882749 OMIM: 620688 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2023-11-29) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2023-11-29) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein C (HNRNPC), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Rev	rev	HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein C (HNRNPC), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPC is increased by RRE	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G36145 (e-PCR)
- UniSTS:11024

RH68331 (e-PCR)
- UniSTS:76587

G36108 (e-PCR)
- UniSTS:43323

WI-19322 (e-PCR)
- UniSTS:27971

RH66344 (e-PCR)
- UniSTS:68692

RH70234 (e-PCR)
- UniSTS:64639

RH118907 (e-PCR)
- UniSTS:138899

RH80802 (e-PCR)
- UniSTS:87204

HNRPC_2223 (e-PCR)
- UniSTS:280755

G43228 (e-PCR)
- UniSTS:94900

G35991 (e-PCR)
- UniSTS:9153

Clone Names

MGC104306, MGC105117, MGC117353, MGC131677

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosomal DNA binding	HDA more info	PubMed
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomerase RNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA splicing	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	HDA more info	PubMed
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	HDA more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	HDA more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed
part_of telomerase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoproteins C1/C2

Names: heterogeneous nuclear ribonucleoprotein C (C1/C2); hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029011.1 RefSeqGene

Range

5038..65333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001077442.2 → NP_001070910.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

See identical proteins and their annotated locations for NP_001070910.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode isoform a, also known as isoform C2.

Source sequence(s)

AB209527, AL135744, BC108658, DB449514

Consensus CDS

CCDS41915.1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Related

ENSP00000452276.1, ENST00000557201.5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_001077443.2 → NP_001070911.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

See identical proteins and their annotated locations for NP_001070911.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment compared to variant 1. The resulting isoform (b, also known as isoform C1) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode isoform b.

Source sequence(s)

AL135744, BC108658, DB449514

Consensus CDS

CCDS45079.1

UniProtKB/TrEMBL

B3KX96

Related

ENSP00000338095.6, ENST00000336053.10

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_004500.4 → NP_004491.2 heterogeneous nuclear ribonucleoproteins C1/C2 isoform b

See identical proteins and their annotated locations for NP_004491.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b, also known as isoform C1) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode isoform b.

Source sequence(s)

AL135744, BC003394, DB449514

Consensus CDS

CCDS45079.1

UniProtKB/TrEMBL

B3KX96

Related

ENSP00000450544.1, ENST00000553300.6

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
NM_031314.3 → NP_112604.2 heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

See identical proteins and their annotated locations for NP_112604.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a, also known as isoform C2). Variants 1 and 3 both encode isoform a.

Source sequence(s)

AB209527, AL135744, DB449514

Consensus CDS

CCDS41915.1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Related

ENSP00000451291.1, ENST00000554455.5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

21209147..21269442 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536712.3 → XP_011535014.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

See identical proteins and their annotated locations for XP_011535014.1

UniProtKB/TrEMBL

B3KX96

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_011536708.2 → XP_011535010.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

See identical proteins and their annotated locations for XP_011535010.1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_006720125.4 → XP_006720188.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

See identical proteins and their annotated locations for XP_006720188.1

UniProtKB/TrEMBL

B3KX96

Related

ENSP00000451176.1, ENST00000556897.5

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_011536710.3 → XP_011535012.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

See identical proteins and their annotated locations for XP_011535012.1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_017021252.3 → XP_016876741.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

UniProtKB/TrEMBL

B3KX96

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_017021253.3 → XP_016876742.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

UniProtKB/TrEMBL

B3KX96

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_011536709.4 → XP_011535011.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

See identical proteins and their annotated locations for XP_011535011.1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Related

ENSP00000404848.2, ENST00000420743.6

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_024449558.2 → XP_024305326.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

UniProtKB/TrEMBL

B3KX96

Related

ENSP00000442816.1, ENST00000430246.6

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_024449556.2 → XP_024305324.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_024449559.2 → XP_024305327.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2

UniProtKB/TrEMBL

B3KX96

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_024449557.2 → XP_024305325.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3

UniProtKB/TrEMBL

A8K9A4

Conserved Domains (1) summary

cd12603
Location:10 → 93

RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
XM_047431331.1 → XP_047287287.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2
XM_047431329.1 → XP_047287285.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

UniProtKB/Swiss-Prot

D3DS19, D3DS22, P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3
XM_047431330.1 → XP_047287286.1 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2