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Nlrx1 NLR family member X1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315599, updated on 2-Nov-2024

Summary

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Official Symbol
Nlrx1provided by RGD
Official Full Name
NLR family member X1provided by RGD
Primary source
RGD:1311293
See related
EnsemblRapid:ENSRNOG00000052386 AllianceGenome:RGD:1311293
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311293
Summary
Predicted to enable ATP binding activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within negative regulation of cytokine production and regulation of defense response. Predicted to be located in plasma membrane. Predicted to be active in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 80.1), Kidney (RPKM 60.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nlrx1 in Genome Data Viewer
Location:
8q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53486866..53503498, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44588476..44606678, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48583559..48600203, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene histone H4 transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage. Zhang Y, et al. FASEB J, 2023 Feb. PMID 36692416
  2. Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome. Tong R, et al. Cell Mol Biol Lett, 2020. PMID 32099552, Free PMC Article
  3. Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1 Downregulation. Guan X, et al. J Stroke Cerebrovasc Dis, 2022 May. PMID 35259612
  4. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Allen IC, et al. Immunity, 2011 Jun 24. PMID 21703540, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage.
    Title: Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage.
  2. Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1 Downregulation.
    Title: Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1 Downregulation.
  3. Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.
    Title: Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of RIG-I signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NLR family member X1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025010.1 → NP_001020181.1  NLR family member X1 precursor

    See identical proteins and their annotated locations for NP_001020181.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089834
    UniProtKB/Swiss-Prot
    Q5FVQ8
    UniProtKB/TrEMBL
    A6J3W5
    Related
    ENSRNOP00000071934.2, ENSRNOT00000077958.3
    Conserved Domains (3) summary
    sd00033
    Location:696 → 724
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:696 → 901
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cl40481
    Location:159 → 318
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53486866..53503498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081422.2 → XP_038937350.1  NLR family member X1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVQ8
    UniProtKB/TrEMBL
    A6J3W5
    Conserved Domains (3) summary
    sd00033
    Location:696 → 724
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:696 → 901
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cl40481
    Location:159 → 318
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  2. XM_039081423.2 → XP_038937351.1  NLR family member X1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVQ8
    UniProtKB/TrEMBL
    A6J3W5
    Conserved Domains (3) summary
    sd00033
    Location:696 → 724
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:696 → 901
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cl40481
    Location:159 → 318
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  3. XM_039081424.2 → XP_038937352.1  NLR family member X1 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVQ8
    UniProtKB/TrEMBL
    A6J3W5
    Conserved Domains (3) summary
    sd00033
    Location:696 → 724
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:696 → 901
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cl40481
    Location:159 → 318
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVQ8.1 GenPept UniProtKB/Swiss-Prot:Q5FVQ8

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