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Eea1 early endosome antigen 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314764, updated on 10-Oct-2024

Summary

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Official Symbol
Eea1provided by RGD
Official Full Name
early endosome antigen 1provided by RGD
Primary source
RGD:1310167
See related
EnsemblRapid:ENSRNOG00000021681 AllianceGenome:RGD:1310167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in recycling endosome. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 206.5), Kidney (RPKM 161.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eea1 in Genome Data Viewer
Location:
7q13
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (32441281..32608808)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (30554686..30722186)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (37101415..37186534)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 1 Neighboring gene uncharacterized LOC102546992 Neighboring gene uncharacterized LOC100912143 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L6, pseudogene 8 Neighboring gene pleckstrin homology and RhoGEF domain containing G7 Neighboring gene EWS RNA-binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. High Resolution Localization of Rab5, EEA1, and Nectin-3 to Tubulobulbar Complexes in the Rat Testis. Adams A, et al. Anat Rec (Hoboken), 2017 Jun. PMID 28176461
  2. Multivalent endosome targeting by homodimeric EEA1. Dumas JJ, et al. Mol Cell, 2001 Nov. PMID 11741531
  3. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. Mu FT, et al. J Biol Chem, 1995 Jun 2. PMID 7768953
  4. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, et al. J Neurosci, 2008 Sep 3. PMID 18768694, Free PMC Article
  5. Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. Nazarewicz RR, et al. J Biol Chem, 2011 Jan 28. PMID 21097843, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in testicular tubulobulbar complexes, associated with large vesicles that lack an association with endoplasmic reticulum
    Title: High Resolution Localization of Rab5, EEA1, and Nectin-3 to Tubulobulbar Complexes in the Rat Testis.
  2. PKC-alpha is a necessary regulator of EEA1-dependent Akt signaling in early endosomes.
    Title: Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission, postsynaptic ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation by host of viral process IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axonal spine ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of serine-pyruvate aminotransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
early endosome antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427400.1 → NP_001414329.1  early endosome antigen 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZV67, A6IG51
    Related
    ENSRNOP00000083105.2, ENSRNOT00000117665.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    32441281..32608808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080107.2 → XP_038936035.1  early endosome antigen 1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K051, F1LUA1
    Related
    ENSRNOP00000071305.2, ENSRNOT00000087297.3
    Conserved Domains (4) summary
    PRK02224
    Location:77 → 637
    PRK02224; DNA double-strand break repair Rad50 ATPase
    TIGR02168
    Location:363 → 1196
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:1343 → 1405
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    NF033930
    Location:1071 → 1327
    pneumo_PspA; pneumococcal surface protein A

  2. XM_039080106.2 → XP_038936034.1  early endosome antigen 1 isoform X4

    UniProtKB/TrEMBL
    F1LUA1
    Conserved Domains (4) summary
    PRK02224
    Location:119 → 679
    PRK02224; DNA double-strand break repair Rad50 ATPase
    TIGR02168
    Location:405 → 1238
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:1385 → 1447
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    NF033930
    Location:1113 → 1369
    pneumo_PspA; pneumococcal surface protein A

  3. XM_063263461.1 → XP_063119531.1  early endosome antigen 1 isoform X3

    Related
    ENSRNOP00000094814.2, ENSRNOT00000107821.2

  4. XM_039080104.2 → XP_038936032.2  early endosome antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIN6
    Related
    ENSRNOP00000092690.2, ENSRNOT00000095444.2

  5. XM_063263460.1 → XP_063119530.1  early endosome antigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A8E0
    Related
    ENSRNOP00000087995.2, ENSRNOT00000103157.2

  6. XM_063263462.1 → XP_063119532.1  early endosome antigen 1 isoform X6

  7. XM_063263463.1 → XP_063119533.1  early endosome antigen 1 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108086.2: Suppressed sequence

    Description
    NM_001108086.2: This RefSeq was removed because the transcript is 5'' incomplete
Nucleotide Protein Strain
Heading Accession and Version

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