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Trip11 thyroid hormone receptor interactor 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314393, updated on 2-Nov-2024

Summary

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Official Symbol
Trip11provided by RGD
Official Full Name
thyroid hormone receptor interactor 11provided by RGD
Primary source
RGD:1586166
See related
EnsemblRapid:ENSRNOG00000005292 AllianceGenome:RGD:1586166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including Golgi ribbon formation; endoplasmic reticulum to Golgi vesicle-mediated transport; and vesicle tethering to Golgi. Predicted to act upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; inner ear receptor cell stereocilium organization; and ventricular septum development. Located in inner acrosomal membrane and outer acrosomal membrane. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 158.5), Heart (RPKM 151.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trip11 in Genome Data Viewer
Location:
6q32
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (126760263..126832619, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120995242..121067693, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125741520..125812926, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene tandem C2 domains, nuclear Neighboring gene fibulin 5 Neighboring gene uncharacterized LOC120103604 Neighboring gene ribosomal protein L37A, pseudogene 6 Neighboring gene ataxin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypomorphic mutations of TRIP11 cause odontochondrodysplasia. Wehrle A, et al. JCI Insight, 2019 Feb 7. PMID 30728324, Free PMC Article
  2. Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210. Sato K, et al. Mol Biol Cell, 2015 Feb 1. PMID 25473115, Free PMC Article
  3. GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Kierszenbaum AL, et al. Dev Dyn, 2011 Mar. PMID 21337470, Free PMC Article
  4. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. Follit JA, et al. PLoS Genet, 2008 Dec. PMID 19112494, Free PMC Article
  5. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. Smits P, et al. N Engl J Med, 2010 Jan 21. PMID 20089971, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle tethering to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in inner acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thyroid receptor-interacting protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412193.2 → NP_001399122.1  thyroid receptor-interacting protein 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000007061.9, ENSRNOT00000007061.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    126760263..126832619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240470.5 → XP_006240532.1  thyroid receptor-interacting protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKA2, D4ABD7
    Conserved Domains (1) summary
    COG1196
    Location:312 → 1162
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_039112358.2 → XP_038968286.1  thyroid receptor-interacting protein 11 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:6 → 739
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10375
    Location:1278 → 1323
    GRAB; GRIP-related Arf-binding domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191772.1: Suppressed sequence

    Description
    NM_001191772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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