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Mideas mitotic deacetylase associated SANT domain protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 314306, updated on 2-Nov-2024

Summary

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Official Symbol
Mideasprovided by RGD
Official Full Name
mitotic deacetylase associated SANT domain proteinprovided by RGD
Primary source
RGD:1306119
See related
EnsemblRapid:ENSRNOG00000010653 AllianceGenome:RGD:1306119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Elmsan1; RGD1306119
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 64.9), Lung (RPKM 48.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mideas in Genome Data Viewer
Location:
6q31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109519011..109585631, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103784779..103854470, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107633762..107703462, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479231 Neighboring gene acyl-CoA thioesterase 6 Neighboring gene dynein, axonemal, light chain 1 Neighboring gene uncharacterized LOC120103573 Neighboring gene PNMA family member 1 Neighboring gene uncharacterized LOC134479232 Neighboring gene prostaglandin reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitotic deacetylase-associated SANT domain protein
Names
ELM2 and Myb/SANT domain containing 1
ELM2 and Myb/SANT-like domain containing 1
ELM2 and SANT domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169116.2 → NP_001162587.1  mitotic deacetylase-associated SANT domain protein

    See identical proteins and their annotated locations for NP_001162587.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JDT5, D4ACA6
    Related
    ENSRNOP00000014158.6, ENSRNOT00000014158.8
    Conserved Domains (2) summary
    pfam01448
    Location:715 → 770
    ELM2; ELM2 domain
    cl21498
    Location:824 → 868
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109519011..109585631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764791.4 → XP_008763013.1  mitotic deacetylase-associated SANT domain protein isoform X1

    See identical proteins and their annotated locations for XP_008763013.1

    UniProtKB/TrEMBL
    A6JDT5, D4ACA6
    Conserved Domains (2) summary
    pfam01448
    Location:715 → 770
    ELM2; ELM2 domain
    cl21498
    Location:824 → 868
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. XM_039112308.2 → XP_038968236.1  mitotic deacetylase-associated SANT domain protein isoform X2

    UniProtKB/TrEMBL
    A6JDT5
    Related
    ENSRNOP00000107715.1, ENSRNOT00000135949.1
    Conserved Domains (3) summary
    PHA03247
    Location:279 → 741
    PHA03247; large tegument protein UL36; Provisional
    pfam01448
    Location:715 → 770
    ELM2; ELM2 domain
    cl21498
    Location:824 → 868
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein Strain
Heading Accession and Version

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