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Pi4KIIIalpha Phosphatidylinositol 4-kinase III alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31247, updated on 2-Nov-2024

Summary

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Official Symbol
Pi4KIIIalphaprovided by FlyBase
Official Full Name
Phosphatidylinositol 4-kinase III alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0267350
Locus tag
Dmel_CG10260
See related
AllianceGenome:FB:FBgn0267350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10260; Dmel\CG10260; EG:BACR7C10.2; l(1)17-59; l(1)3Ah; l(1)VA722; l(1)zw2; PI4K; PI4KIIIA; PI4KIIIalpha; PI4KIII[[alpha]]; PI4KinaseIIIalpha; stt4; Stt4; zw-2; ZW-2; zw2
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including phosphatidylinositol phosphate biosynthetic process; positive regulation of smoothened signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to several human genes including PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Pi4KIIIalpha in Genome Data Viewer
Location:
3A8-3A8; 1-1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2624804..2633672)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2518837..2527705)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 3A Neighboring gene seipin Neighboring gene brivido-3 Neighboring gene shaggy Neighboring gene long non-coding RNA:CR45197 Neighboring gene Helix loop helix protein 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene. Zheng C, et al. Epigenetics, 2024 Dec. PMID 38525798, Free PMC Article
  2. The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset. Williams BC, et al. J Cell Biol, 1992 Aug. PMID 1339459, Free PMC Article
  3. Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila. Zhang X, et al. J Neurosci, 2017 May 10. PMID 28424219, Free PMC Article
  4. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila. Zhang Q, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34894559
  5. An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily. Bourouis M, et al. EMBO J, 1990 Sep. PMID 2118107, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A PI4KIIIalpha protein complex is required for cell viability during Drosophila wing development.
    Title: A PI4KIIIα protein complex is required for cell viability during Drosophila wing development.
  2. Here, the authors show that the sole type I phosphatidylinositol transfer protein, Vibrator, controls asymmetric division of Drosophilaneural stem cells (NSCs) by physically anchoring myosin II regulatory light chain, Sqh, to the NSC cortex.
    Title: Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.
  3. This study suggests the RBO-PI4KIIIalpha complex as a novel therapeutic target, and PI4KIIIalpha inhibitors as new drug candidates.
    Title: Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila.
  4. PI4KIIIalpha is a vital regulator of a functionally distinct pool of PtdIns4P that is essential for PtdIns(4,5)P2-dependent processes in Drosophila development.
    Title: PI4KIIIα is required for cortical integrity and cell polarity during Drosophila oogenesis.
  5. Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling.
    Title: Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase III alpha
Names
CG10260-PC
CG10260-PD
PI4KIIIalpha
Pi4KIIIalpha-PC
Pi4KIIIalpha-PD
lethal (1) 3Ah
phosphatidylinositol 4-kinase IIIalpha
zeste-white 2
NP_001259191.1
NP_570014.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2624804..2633672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272262.2 → NP_001259191.1  phosphatidylinositol 4-kinase III alpha, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259191.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDM4, Q9U1K8
    Conserved Domains (2) summary
    cd00871
    Location:1600 → 1775
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:1836 → 2153
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha

  2. NM_130658.3 → NP_570014.3  phosphatidylinositol 4-kinase III alpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570014.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K8, Q9W4X4
    Conserved Domains (2) summary
    cd00871
    Location:1580 → 1755
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:1816 → 2133
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDM4 M9PDM4
Q8MYR7 Q8MYR7
Q9U1K8 Q9U1K8
Q9W4X4 Q9W4X4

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