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PIG-K Phosphatidylinositol glycan anchor biosynthesis class K [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31163, updated on 18-Sep-2024

Summary

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Official Symbol
PIG-Kprovided by FlyBase
Official Full Name
Phosphatidylinositol glycan anchor biosynthesis class Kprovided by FlyBase
Primary source
FLYBASE:FBgn0023545
Locus tag
Dmel_CG4406
See related
AllianceGenome:FB:FBgn0023545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4406; CG4406; Dmel\CG4406; EG:133E12.3; PIGK
Summary
Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein and protein localization to cell surface. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See PIG-K in Genome Data Viewer
Location:
2C1-2C1; 1-0.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2007911..2009364, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1901944..1903397, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 4 Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45478 Neighboring gene mir-2496 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
  2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
  3. Drosophila Trf4-1 involves in mRNA and primary miRNA transcription. Liu Y, et al. Biochem Biophys Res Commun, 2019 Apr 16. PMID 30837153
  4. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. Hallacli E, et al. Mol Cell, 2012 Nov 30. PMID 23084835
  5. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GPI-anchor transamidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GPI-anchor transamidase activity IEA
Inferred from Electronic Annotation
more info
  
enables GPI-anchor transamidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
part_of GPI-anchor transamidase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol glycan anchor biosynthesis class K
Names
CG4406-PA
PIG-K-PA
NP_569968.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2007911..2009364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130612.4 → NP_569968.2  phosphatidylinositol glycan anchor biosynthesis class K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569968.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46047, Q8T4E1, Q9W538
    Related
    FBpp0070333
    Conserved Domains (1) summary
    cl00042
    Location:35 → 325
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T4E1.1 Q8T4E1

Gene LinkOut

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