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Cyp4g1 Cytochrome P450 4g1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 30986, updated on 18-Sep-2024

Summary

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Official Symbol
Cyp4g1provided by FlyBase
Official Full Name
Cytochrome P450 4g1provided by FlyBase
Primary source
FLYBASE:FBgn0010019
Locus tag
Dmel_CG3972
See related
AllianceGenome:FB:FBgn0010019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4g1; anon-WO0140519.102; ASC-T1; CG3972; cyp4g1; Cyp4G1; CYP4G1; Cyt-P450-A1; Dmel\CG3972; EG:165H7.1; P-450; P-450-A; P450; P450-A; P450A; scgamma; T1
Summary
Enables aldehyde decarbonylase activity. Involved in cuticle hydrocarbon biosynthetic process. Is expressed in adult head; adult heart; embryonic/larval oenocyte; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Cyp4g1 in Genome Data Viewer
Location:
1B4-1B4; 1-0 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (467057..469335, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (361090..363368, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pepsinogen C-like Neighboring gene asense Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ellipsoid body open

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons. Wang Z, et al. Elife, 2022 Dec 6. PMID 36473178, Free PMC Article
  2. Origin and evolution of the CYP4G subfamily in insects, cytochrome P450 enzymes involved in cuticular hydrocarbon synthesis. Feyereisen R. Mol Phylogenet Evol, 2020 Feb. PMID 31805344
  3. An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Qiu Y, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927409, Free PMC Article
  4. A single p450 allele associated with insecticide resistance in Drosophila. Daborn PJ, et al. Science, 2002 Sep 27. PMID 12351787
  5. Isolation of insecticide resistance-related forms of cytochrome P-450 from Drosophila melanogaster. Sundseth SS, et al. Biochem J, 1990 Jan 1. PMID 2105716, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbon-carbon lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cuticle hydrocarbon biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 4g1
Names
Achaete-scute complex transcript 1
CG3972-PA
Cyp4g1-PA
cytochrome P450
cytochrome P450 A1
cytochrome P450-4g1
NP_525031.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    467057..469335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080292.4 → NP_525031.1  cytochrome P450 4g1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UN25, Q24126, Q95U60, Q9V3S0
    Related
    FBpp0070094
    Conserved Domains (1) summary
    pfam00067
    Location:58 → 518
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3S0.1 Q9V3S0

Gene LinkOut

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