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igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 [ Danio rerio (zebrafish) ]

Gene ID: 30967, updated on 2-Nov-2024

Summary

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Official Symbol
igf2bp3provided by ZNC
Official Full Name
insulin-like growth factor 2 mRNA binding protein 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-000308-1
See related
Ensembl:ENSDARG00000010266 AllianceGenome:ZFIN:ZDB-GENE-000308-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dvr1rbp; zVg1RBP; wu:fb79c12; wu:fe06h09
Summary
Enables mRNA 3'-UTR binding activity. Acts upstream of or within several processes, including germ cell migration; regulation of embryonic development; and sex determination. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytosol and nucleus. Is expressed in female organism; male organism; oocyte stage I; oocyte stage IV; and oocyte stage V. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See igf2bp3 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (20201289..20245494)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (20616654..20661378)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene transformer 2 alpha homolog Neighboring gene uncharacterized LOC137488504 Neighboring gene glycoprotein (transmembrane) nmb Neighboring gene oxidoreductase NAD-binding domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cardiac Regeneration and Tumor Growth-What Do They Have in Common? Dicks S, et al. Front Genet, 2020. PMID 33362851, Free PMC Article
  2. The RNA-binding protein Vg1 RBP is required for cell migration during early neural development. Yaniv K, et al. Development, 2003 Dec. PMID 14522877
  3. Vg1 RBP intracellular distribution and evolutionarily conserved expression at multiple stages during development. Zhang Q, et al. Mech Dev, 1999 Oct. PMID 10525193
  4. The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo. Gaynes JA, et al. PLoS One, 2015. PMID 26325373, Free PMC Article
  5. Possible involvement of insulin-like growth factor 2 mRNA-binding protein 3 in zebrafish oocyte maturation as a novel cyclin B1 mRNA-binding protein that represses the translation in immature oocytes. Takahashi K, et al. Biochem Biophys Res Commun, 2014 May 23. PMID 24735541

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.
    Title: The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish.
  2. Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish.
    Title: Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CRD-mediated mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
insulin-like growth factor 2 mRNA-binding protein 3
Names
IGF-II mRNA-binding protein 3
IGF2 mRNA-binding protein 3
IMP-3
IMP3
VICKZ family member 3
Vg1 RBP
decapentaplegic and Vg-related 1 RNA-binding protein
vg1 RNA-binding protein
vg1-RBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131491.2 → NP_571566.1  insulin-like growth factor 2 mRNA-binding protein 3

    See identical proteins and their annotated locations for NP_571566.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045873
    UniProtKB/Swiss-Prot
    Q9PW80
    UniProtKB/TrEMBL
    B2GT58
    Related
    ENSDARP00000010878.6, ENSDART00000010140.7
    Conserved Domains (3) summary
    cd00105
    Location:278 → 343
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd12627
    Location:1 → 77
    RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd12630
    Location:81 → 156
    RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    20201289..20245494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294198.4 → XP_009292473.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IYT0, A0A8M3AKY0
    Related
    ENSDARP00000140941.1, ENSDART00000163026.2
    Conserved Domains (3) summary
    cd00105
    Location:278 → 343
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd12627
    Location:1 → 77
    RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd12630
    Location:81 → 156
    RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PW80.1 GenPept UniProtKB/Swiss-Prot:Q9PW80

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