Uvrag UV radiation resistance associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uvragprovided by RGD
Official Full Name: UV radiation resistance associatedprovided by RGD
Primary source: RGD:1589754
See related: EnsemblRapid:ENSRNOG00000016206 AllianceGenome:RGD:1589754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity and SNARE binding activity. Predicted to be involved in several processes, including SNARE complex assembly; double-strand break repair via classical nonhomologous end joining; and microtubule cytoskeleton organization. Predicted to act upstream of or within viral entry into host cell. Predicted to be located in several cellular components, including cytoplasmic vesicle; midbody; and vacuole. Predicted to be part of protein-containing complex. Predicted to be active in endosome and lytic vacuole. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 105.5), Lung (RPKM 92.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (162596514..162854348, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153185356..153442200, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163844804..164101568, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cultured hippocampal neurons, MAP2 and p63 were found to concomitantly compartmentalize to the dendritic processes during neuronal differentiation.
Title: Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

BE105509 (e-PCR)
- UniSTS:245859

AW535888 (e-PCR)
- UniSTS:260994

D1Rat422 (e-PCR), detects polymorphism
- UniSTS:227206

AU048854 (e-PCR)
- UniSTS:145304

D1Rat468 (e-PCR), detects polymorphism
- UniSTS:227250

BM387130 (e-PCR)
- UniSTS:261303

AU047929 (e-PCR)
- UniSTS:110038

AA957656 (e-PCR)
- UniSTS:261601

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in SNARE complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within SNARE complex assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via classical nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in maintenance of Golgi location	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in lytic vacuole	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class III	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UV radiation resistance-associated gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107536.1 → NP_001101006.1 UV radiation resistance-associated gene protein isoform 2

See identical proteins and their annotated locations for NP_001101006.1

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A6I6F5

Conserved Domains (2) summary

cd00030
Location:44 → 118

C2; C2 domain

pfam10186
Location:215 → 394

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
NM_001401542.1 → NP_001388471.1 UV radiation resistance-associated gene protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I6F4, D3ZKE1

Related

ENSRNOP00000022176.6, ENSRNOT00000022176.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

162596514..162854348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039113251.2 → XP_038969179.1 UV radiation resistance-associated gene protein isoform X2

Conserved Domains (1) summary

pfam10186
Location:50 → 173

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
XM_039113238.2 → XP_038969166.1 UV radiation resistance-associated gene protein isoform X1

Conserved Domains (2) summary

cd00030
Location:44 → 118

C2; C2 domain

pfam10186
Location:183 → 441

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
XM_039113255.2 → XP_038969183.1 UV radiation resistance-associated gene protein isoform X3

UniProtKB/TrEMBL

A6I6F6

Conserved Domains (2) summary

pfam10186
Location:183 → 394

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

pfam17649
Location:39 → 262

VPS38; Vacuolar protein sorting 38