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Sphk2 sphingosine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308589, updated on 18-Sep-2024

Summary

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Official Symbol
Sphk2provided by RGD
Official Full Name
sphingosine kinase 2provided by RGD
Primary source
RGD:1307757
See related
EnsemblRapid:ENSRNOG00000021032 AllianceGenome:RGD:1307757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable kinase activity; nucleosomal histone binding activity; and sphingosine-1-phosphate receptor activity. Involved in female pregnancy. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 86.5), Adrenal (RPKM 75.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sphk2 in Genome Data Viewer
Location:
1q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105317332..105324985, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96180872..96188592, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101692972..101700604, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 11 Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway. Zhang R, et al. Exp Mol Pathol, 2016 Feb. PMID 26621495
  2. Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain. Dominguez G, et al. Acta Neuropathol Commun, 2018 Apr 3. PMID 29615132, Free PMC Article
  3. ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets. Mastrandrea LD, et al. J Lipid Res, 2010 Aug. PMID 20371493, Free PMC Article
  4. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. Kharel Y, et al. J Biol Chem, 2005 Nov 4. PMID 16093248
  5. Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. Sivasubramanian M, et al. Neuroscience, 2015 Apr 2. PMID 25637806

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hypoxic preconditioning significantly increased SphK2 expression in primary cardiomyocytes
    Title: Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.
  2. Glucose-supported beta-cell growth appears to be in part mediated by SPHK activity.
    Title: ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets.
  3. S1P modulates spinal nociceptive processing through inhibition of neuronal cAMP synthesis and sphingosine kinase 1, but not sphingosine kinase 2
    Title: Sphingosine 1-phosphate modulates spinal nociceptive processing.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D-erythro-sphingosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-erythro-sphingosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables sphingosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingosine-1-phosphate receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to phorbol 13-acetate 12-myristate ISO
Inferred from Sequence Orthology
more info
  
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphinganine-1-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphinganine-1-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sphingosine kinase 2
NP_001012066.1
XP_006229147.1
XP_008757605.1
XP_038968225.1
XP_038968232.1
XP_063118198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012066.1 → NP_001012066.1  sphingosine kinase 2

    See identical proteins and their annotated locations for NP_001012066.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079120
    UniProtKB/TrEMBL
    A6JB73, F7FEJ8, Q6AYB2
    Related
    ENSRNOP00000028549.4, ENSRNOT00000028549.7
    Conserved Domains (1) summary
    PLN02958
    Location:152 → 607
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105317332..105324985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229085.4 → XP_006229147.1  sphingosine kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006229147.1

    UniProtKB/TrEMBL
    A6JB73, F7FEJ8, Q6AYB2
    Conserved Domains (1) summary
    PLN02958
    Location:152 → 607
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

  2. XM_008759383.3 → XP_008757605.1  sphingosine kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_008757605.1

    UniProtKB/TrEMBL
    A6JB73, F7FEJ8, Q6AYB2
    Conserved Domains (1) summary
    PLN02958
    Location:152 → 607
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

  3. XM_039112304.2 → XP_038968232.1  sphingosine kinase 2 isoform X1

    UniProtKB/TrEMBL
    A6JB73, F7FEJ8, Q6AYB2
    Conserved Domains (1) summary
    PLN02958
    Location:152 → 607
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

  4. XM_039112297.2 → XP_038968225.1  sphingosine kinase 2 isoform X1

    UniProtKB/TrEMBL
    A6JB73, F7FEJ8, Q6AYB2
    Conserved Domains (1) summary
    PLN02958
    Location:152 → 607
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

  5. XM_063262128.1 → XP_063118198.1  sphingosine kinase 2 isoform X1

    UniProtKB/TrEMBL
    A6JB73, F7FEJ8, Q6AYB2
Nucleotide Protein Strain
Heading Accession and Version

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