U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UL55 envelope glycoprotein B [ Human betaherpesvirus 5 ]

Gene ID: 3077424, updated on 20-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
UL55
Gene description
envelope glycoprotein B
Locus tag
HHV5wtgp060
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_006273.2 (82066..84789, complement)

NC_006273.2Genomic Context describing neighboring genes Neighboring gene DNA packaging protein UL32 Neighboring gene nuclear egress lamina protein Neighboring gene DNA polymerase catalytic subunit Neighboring gene DNA packaging terminase subunit 2 Neighboring gene single-stranded DNA-binding protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step. Ye X, et al. PLoS Pathog, 2020 Aug. PMID 32745149, Free PMC Article
  2. Cell Fusion Induced by a Fusion-Active Form of Human Cytomegalovirus Glycoprotein B (gB) Is Inhibited by Antibodies Directed at Antigenic Domain 5 in the Ectodomain of gB. Reuter N, et al. J Virol, 2020 Aug 31. PMID 32641474, Free PMC Article
  3. Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability. Tang J, et al. Proc Natl Acad Sci U S A, 2019 Sep 3. PMID 31427511, Free PMC Article
  4. Palmitoylation Strengthens Cholesterol-dependent Multimerization and Fusion Activity of Human Cytomegalovirus Glycoprotein B (gB). Patrone M, et al. J Biol Chem, 2016 Feb 26. PMID 26694613, Free PMC Article
  5. Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus. Wiegers AK, et al. J Virol, 2015 Jan. PMID 25320309, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.
    Title: A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.
  2. Clinical Features, Treatment Courses, and Distribution of Cytomegalovirus Genotypes among Thrombocytopenia Patients Aged Younger than 12 Months.
    Title: Clinical Features, Treatment Courses, and Distribution of Cytomegalovirus Genotypes among Thrombocytopenia Patients Aged Younger than 12 Months.
  3. Cell Fusion Induced by a Fusion-Active Form of Human Cytomegalovirus Glycoprotein B (gB) Is Inhibited by Antibodies Directed at Antigenic Domain 5 in the Ectodomain of gB.
    Title: Cell Fusion Induced by a Fusion-Active Form of Human Cytomegalovirus Glycoprotein B (gB) Is Inhibited by Antibodies Directed at Antigenic Domain 5 in the Ectodomain of gB.
  4. Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
    Title: Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
  5. HCMV-induced signaling through gB-EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes.
    Title: HCMV-induced signaling through gB-EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes.
  6. These results suggest that gB variants with increased fusogenicity accelerate viral entry, cause cell fusion, and thereby compromise genome stability. They further suggest the ATM-PIDDosome-caspase-2 signaling axis alerts the cell of potentially dangerous cell fusion.
    Title: Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability.
  7. The authors identified DC-SIGN amino acid residues involved in interaction with cytomegalovirus envelope glycoprotein B (gB) and demonstrated that the antigenic domain 5 on gB is involved in the interaction with DC-SIGN. Antibody-mediated blockades allowed them to identify DC-SIGN as a major human cytomegalovirus attachment receptor on monocyte-derived dendritic cells.
    Title: Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B.
  8. Data suggest that, unique among herpesviral gB proteins, the human cytomegalovirus fusion factor gB/UL55 has a Cys residue in the C-terminal region that is palmitoylated and mediates self-association of purified gB/UL55.
    Title: Palmitoylation Strengthens Cholesterol-dependent Multimerization and Fusion Activity of Human Cytomegalovirus Glycoprotein B (gB).
  9. Taken together, these data indicate that the YNND epitope of cytomegalovirus glycoprotein B (gB) represents an important target for anti-gB antibody responses as well as for anti-antigenic domain 5 virus-neutralizing antibodies
    Title: Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus.
  10. These data support the hypothesis that human cytomegalovirus gH/gL binds cellular receptors before triggering gB, which acts as the fusion protein.
    Title: Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

  • core gene

General protein information

Go to the top of the page Help
Preferred Names
envelope glycoprotein B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006273.2 Reference assembly

    Range
    82066..84789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_081514.1 envelope glycoprotein B [Human betaherpesvirus 5]

    See identical proteins and their annotated locations for YP_081514.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HB53
    UniProtKB/TrEMBL
    A0A076JPC7, A0A0G2TSH2, A0A0G2TTV6, C8BL09, C8CPF6, Q6SW76, V9PU08
    Conserved Domains (1) summary
    PHA03231
    Location:55 → 906
    PHA03231; glycoprotein BALF4; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.