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Cfap20 cilia and flagella associated protein 20 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307642, updated on 17-Aug-2024

Summary

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Official Symbol
Cfap20provided by RGD
Official Full Name
cilia and flagella associated protein 20provided by RGD
Primary source
RGD:1308493
See related
EnsemblRapid:ENSRNOG00000042179 AllianceGenome:RGD:1308493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gtl3
Summary
Predicted to be involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cell motility. Predicted to be located in centriole; cilium; and nucleoplasm. Predicted to be active in ciliary basal body and motile cilium. Orthologous to human CFAP20 (cilia and flagella associated protein 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 280.6), Lung (RPKM 179.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9614265..9628612)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9608867..9622558)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10024938..10038838)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 113 Neighboring gene casein kinase 2 alpha 2 Neighboring gene matrix metallopeptidase 15 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium. Laligné C, et al. Eukaryot Cell, 2010 Apr. PMID 20118210, Free PMC Article
  2. Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules. Mendes Maia T, et al. Biol Open, 2014 Feb 15. PMID 24414207, Free PMC Article
  3. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124689

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium beat frequency involved in ciliary motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axonemal B tubule inner sheath ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 20
Names
UPF0468 protein C16orf80 homolog
gene trap locus 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037978.2 → NP_001033067.1  cilia- and flagella-associated protein 20 isoform 2

    See identical proteins and their annotated locations for NP_001033067.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q499T7
    UniProtKB/TrEMBL
    A0A8I5ZUW3
    Conserved Domains (1) summary
    pfam05018
    Location:6 → 144
    DUF667; Protein of unknown function (DUF667)

  2. NM_001399181.1 → NP_001386110.1  cilia- and flagella-associated protein 20 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0H2UI05, A0A8I5ZUW3, A6JY06
    Related
    ENSRNOP00000058109.4, ENSRNOT00000061392.6
    Conserved Domains (1) summary
    pfam05018
    Location:1 → 185
    DUF667; Protein of unknown function (DUF667)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9614265..9628612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097696.2 → XP_038953624.1  cilia- and flagella-associated protein 20 isoform X1

    Conserved Domains (1) summary
    pfam05018
    Location:1 → 185
    DUF667; Protein of unknown function (DUF667)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499T7.1 GenPept UniProtKB/Swiss-Prot:Q499T7

Gene LinkOut

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