pcmt protein-L-isoaspartate (D-aspartate) O-methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcmtprovided by ZNC
Official Full Name: protein-L-isoaspartate (D-aspartate) O-methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-134
See related: Ensembl:ENSDARG00000015201 AllianceGenome:ZFIN:ZDB-GENE-990415-134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pimt; fj13d06; wu:fj13d06; etID309741.20
Summary: Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Acts upstream of or within regulation of calcium-mediated signaling. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm. Is expressed in brain; heart; liver; and pleuroperitoneal region. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (1293985..1314427, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (1273159..1293747, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fj13d06.x1 (e-PCR)
- UniSTS:188436

PCMT (e-PCR)
- UniSTS:205423

fb82c05.y1 (e-PCR)
- UniSTS:191674

pcmt (e-PCR), detects polymorphism
- UniSTS:205536

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in protein methylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Names: l-isoaspartyl protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase; protein-L-isoaspartate (D-aspartate) O-methyltransferase 1; protein-beta-aspartate methyltransferase

NP_571540.1

EC 2.1.1.77

XP_005160364.2

EC 2.1.1.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131465.3 → NP_571540.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase

See identical proteins and their annotated locations for NP_571540.1

Status: VALIDATED

Source sequence(s)

BX248418, CR536610

UniProtKB/Swiss-Prot

Q92047

Related

ENSDARP00000119861.1, ENSDART00000144288.3

Conserved Domains (2) summary

pfam01135
Location:8 → 216

PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

cl17173
Location:11 → 218

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...