U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bmpr1ba bone morphogenetic protein receptor, type IBa [ Danio rerio (zebrafish) ]

Gene ID: 30742, updated on 19-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
bmpr1baprovided by ZNC
Official Full Name
bone morphogenetic protein receptor, type IBaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-991208-8
See related
Ensembl:ENSDARG00000104100 AllianceGenome:ZFIN:ZDB-GENE-991208-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
BR1b; alk6tr; bmpr1b; zALK-6; BMPR-IB; zgc:92220
Summary
Predicted to enable SMAD binding activity and transforming growth factor beta receptor activity, type I. Acts upstream of or within BMP signaling pathway and determination of dorsal identity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; margin; nervous system; optic primordium; and ovarian follicle. Human ortholog(s) of this gene implicated in brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See bmpr1ba in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (7488053..7712160, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (6996909..7206866, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110437727 Neighboring gene unc-5 netrin receptor Ca Neighboring gene angiopoietin-related protein 2 pseudogene Neighboring gene uncharacterized LOC110439803 Neighboring gene PDZ and LIM domain 5a Neighboring gene opsin 4xb

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Maurya AK, et al. Development, 2011 Feb. PMID 21266411
  2. Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Owen N, et al. Genet Med, 2022 May. PMID 35034853
  3. BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development. Huang S, et al. Front Cell Neurosci, 2019. PMID 31849612, Free PMC Article
  4. Blood flow and Bmp signaling control endocardial chamber morphogenesis. Dietrich AC, et al. Dev Cell, 2014 Aug 25. PMID 25158852
  5. BMP regulation of myogenesis in zebrafish. Patterson SE, et al. Dev Dyn, 2010 Mar. PMID 20151472, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC92220

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
  
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
bone morphogenetic protein receptor type-1B
Names
alk6
bone morphogenetic protein receptor, type 1b
bone morphogenetic protein receptor, type 1ba
NP_571532.1
XP_021331677.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131457.2 → NP_571532.1  bone morphogenetic protein receptor type-1B precursor

    See identical proteins and their annotated locations for NP_571532.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081625
    UniProtKB/TrEMBL
    Q66HY2, Q9W629
    Related
    ENSDARP00000140548.1, ENSDART00000168820.2
    Conserved Domains (3) summary
    smart00220
    Location:233 → 517
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14219
    Location:226 → 530
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:61 → 138
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    7488053..7712160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476002.1 → XP_021331677.1  bone morphogenetic protein receptor type-1B isoform X1

    UniProtKB/TrEMBL
    A0A8M9PJN6
    Related
    ENSDARP00000132631.1, ENSDART00000158913.2
    Conserved Domains (3) summary
    cd14219
    Location:194 → 498
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:29 → 102
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:171 → 198
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.