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pou2f1a POU class 2 homeobox 1a [ Danio rerio (zebrafish) ]

Gene ID: 30715, updated on 2-Nov-2024

Summary

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Official Symbol
pou2f1aprovided by ZNC
Official Full Name
POU class 2 homeobox 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-185
See related
AllianceGenome:ZFIN:ZDB-GENE-990415-185
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
oct1; Oct-1; pouII1; zgc:109809
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See pou2f1a in Genome Data Viewer
Location:
chromosome: Un
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_018394426.1 (10585..23755)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (49205..61490, complement)

NW_018394426.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 27 Neighboring gene wu:fj30f06 Neighboring gene CD247 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effect-directed analysis reveals inhibition of zebrafish uptake transporter Oatp1d1 by caulerpenyne, a major secondary metabolite from the invasive marine alga Caulerpa taxifolia. Marić P, et al. Chemosphere, 2017 May. PMID 28199941
  2. Organic cation transporters are determinants of oxaliplatin cytotoxicity. Zhang S, et al. Cancer Res, 2006 Sep 1. PMID 16951202, Free PMC Article
  3. Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Fero K, et al. Dis Model Mech, 2014 Feb. PMID 24203884, Free PMC Article
  4. Ecotoxicological profiling of selected cyanobacterial strains using multi-endpoint effect-directed analysis. Marić P, et al. Ecotoxicology, 2020 Jul. PMID 32297059
  5. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Tzvetkov MV, et al. Clin Pharmacol Ther, 2009 Sep. PMID 19536068

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Renal OCT1 expression may be important not only in relation to metformin but with respect to other drugs as well
    Title: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
  2. OCT1 and OCT2 are major determinants of the anticancer activity of oxaliplatin and may contribute to its antitumor specificity.
    Title: Organic cation transporters are determinants of oxaliplatin cytotoxicity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109809

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
POU domain, class 2, transcription factor 1a
Names
octamer-binding transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039974.1 → NP_001035063.1  POU domain, class 2, transcription factor 1a isoform 2

    See identical proteins and their annotated locations for NP_001035063.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098520
    UniProtKB/TrEMBL
    Q4KMK8
    Conserved Domains (2) summary
    smart00352
    Location:151 → 225
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:253 → 307
    Homeobox; Homeobox domain

  2. NM_131438.1 → NP_571513.1  POU domain, class 2, transcription factor 1a isoform 1

    See identical proteins and their annotated locations for NP_571513.1

    Status: PROVISIONAL

    Source sequence(s)
    AF030519
    UniProtKB/TrEMBL
    O42276
    Conserved Domains (2) summary
    smart00352
    Location:176 → 250
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:278 → 332
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NW_018394426.1 Reference GRCz11 Primary Assembly

    Range
    10585..23755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials