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kif23 kinesin family member 23 [ Danio rerio (zebrafish) ]

Gene ID: 30627, updated on 18-Sep-2024

Summary

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Official Symbol
kif23provided by ZNC
Official Full Name
kinesin family member 23provided by ZNC
Primary source
ZFIN:ZDB-GENE-991019-4
See related
Ensembl:ENSDARG00000014943 AllianceGenome:ZFIN:ZDB-GENE-991019-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb738; knsl5; mklp1; zMKLP1; wu:fi30e02; wu:fi39f08
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within cytoskeleton-dependent cytokinesis; embryonic cleavage; and vesicle transport along microtubule. Located in several cellular components, including cleavage furrow; microtubule; and nucleus. Is expressed in proliferative region. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See kif23 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20436274..20458369, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20447208..20469362, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats a Neighboring gene TLE family member 3, transcriptional corepressor a Neighboring gene progestin and adipoQ receptor family member Va Neighboring gene damage-specific DNA binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Multiple roles of the furrow deepening Ca2+ transient during cytokinesis in zebrafish embryos. Li WM, et al. Dev Biol, 2008 Apr 15. PMID 18313658
  2. Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis. Chen MC, et al. Physiol Genomics, 2002 Feb 11. PMID 11842131
  3. Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Rodriguez RS, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Jun. PMID 24667760
  4. Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. González-Rosa JM, et al. Dev Cell, 2018 Feb 26. PMID 29486195, Free PMC Article
  5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109838, MGC192860

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cleavage furrow formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF23
Names
kinesin-like 5
mitotic kinesin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131355.1 → NP_571430.1  kinesin-like protein KIF23

    See identical proteins and their annotated locations for NP_571430.1

    Status: PROVISIONAL

    Source sequence(s)
    AF139990
    UniProtKB/TrEMBL
    A0A0R4IKS5, A0A8N7UZJ3, Q9PUU5
    Related
    ENSDARP00000026695.8, ENSDART00000012241.10
    Conserved Domains (6) summary
    cd01368
    Location:24 → 434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31 → 436
    Kinesin; Kinesin motor domain
    pfam08614
    Location:453 → 633
    ATG16; Autophagy protein 16 (ATG16)
    pfam16046
    Location:535 → 596
    FAM76; FAM76 protein
    pfam16540
    Location:710 → 810
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl23720
    Location:505 → 657
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    20436274..20458369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467587.2 → XP_021323262.1  kinesin-like protein KIF23 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P0Y6
    Conserved Domains (3) summary
    cd01368
    Location:24 → 434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:810 → 913
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl25732
    Location:511 → 684
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_009293529.4 → XP_009291804.1  kinesin-like protein KIF23 isoform X3

    UniProtKB/TrEMBL
    A0A286Y967, A0A8M3AUT8
    Related
    ENSDARP00000143716.1, ENSDART00000177125.2
    Conserved Domains (6) summary
    cd01368
    Location:24 → 449
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31 → 451
    Kinesin; Kinesin motor domain
    pfam08614
    Location:468 → 648
    ATG16; Autophagy protein 16 (ATG16)
    pfam16046
    Location:550 → 611
    FAM76; FAM76 protein
    pfam16540
    Location:725 → 825
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl23720
    Location:520 → 672
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_021467586.2 → XP_021323261.1  kinesin-like protein KIF23 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLX5
    Conserved Domains (3) summary
    cd01368
    Location:24 → 449
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:825 → 928
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    cl25732
    Location:526 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    29838..51882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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