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dlx3b distal-less homeobox 3b [ Danio rerio (zebrafish) ]

Gene ID: 30585, updated on 2-Nov-2024

Summary

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Official Symbol
dlx3bprovided by ZNC
Official Full Name
distal-less homeobox 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-280
See related
Ensembl:ENSDARG00000014626 AllianceGenome:ZFIN:ZDB-GENE-980526-280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dlx3; dlx-3; zgc:91827; id:ibd3531; wu:fb83f11
Summary
Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including inner ear development; olfactory placode formation; and skeletal system development. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; neural crest; neural plate; neurogenic field; and pharyngeal arch. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dlx3b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5708423..5711920)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5673466..5676963)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene integrin, alpha 3b Neighboring gene microRNA mir-2186 Neighboring gene distal-less homeobox 4b Neighboring gene si:ch211-131k2.2 Neighboring gene K(lysine) acetyltransferase 7b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish eya1 gene and its expression pattern during embryogenesis. Sahly I, et al. Dev Genes Evol, 1999 Jul. PMID 10370123
  2. An Assay for Systematically Quantifying the Vestibulo-Ocular Reflex to Assess Vestibular Function in Zebrafish Larvae. Sun P, et al. Front Cell Neurosci, 2018. PMID 30186115, Free PMC Article
  3. N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish. Hong E, et al. Development, 2006 Oct. PMID 16943271
  4. Exogenous retinoic acid induces a stage-specific, transient and progressive extension of Sonic hedgehog expression across the pectoral fin bud of zebrafish. Hoffman L, et al. Int J Dev Biol, 2002. PMID 12455633
  5. Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing. Harden MV, et al. Dev Dyn, 2012 Jul. PMID 22539261, Free PMC Article

See all (292) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.
    Title: Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.
  2. Foxi1 and Dlx3b/4b regulate the neuronal and sensory lineages of the inner ear.
    Title: Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage.
  3. the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
    Title: hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.
  4. These results provide insight into the mechanisms of preplacodal region (PPR) specification as well as the role of dlx3b/4b function in PPR and otic placode induction.
    Title: dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity.
  5. Dlx3b provide competence for cells to respond to Fgf and form an otic placode
    Title: Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b.
  6. Data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via bone morphogenic protein activity.
    Title: dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within endocrine system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner ear receptor cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lens fiber cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within olfactory placode development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within olfactory placode formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic placode formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic placode formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otic vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otic vesicle formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic vesicle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otic vesicle morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otolith development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tooth mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trigeminal nerve development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein Dlx3b
Names
distal-less homeobox gene 3b
distal-less homeobox protein 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131322.2 → NP_571397.2  homeobox protein Dlx3b

    See identical proteins and their annotated locations for NP_571397.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078386
    UniProtKB/Swiss-Prot
    Q01702
    UniProtKB/TrEMBL
    B2GNK2, Q6DBS2
    Related
    ENSDARP00000022291.5, ENSDART00000017191.7
    Conserved Domains (2) summary
    pfam00046
    Location:128 → 181
    Homeobox; Homeobox domain
    pfam12413
    Location:28 → 104
    DLL_N; Homeobox protein distal-less-like N terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    5708423..5711920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01702.1 GenPept UniProtKB/Swiss-Prot:Q01702

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