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Zfp68 zinc finger protein 68 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304337, updated on 17-Aug-2024

Summary

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Official Symbol
Zfp68provided by RGD
Official Full Name
zinc finger protein 68provided by RGD
Primary source
RGD:1310463
See related
EnsemblRapid:ENSRNOG00000001317 AllianceGenome:RGD:1310463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 138.8), Thymus (RPKM 136.4) and 9 other tissues See more
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Genomic context

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See Zfp68 in Genome Data Viewer
Location:
12q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21139838..21154775)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16026058..16040995)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18152596..18167523)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B, pseudogene Neighboring gene zinc finger protein 846 Neighboring gene ribosomal protein S8, pseudogene 9 Neighboring gene vomeronasal 2 receptor, pseudogene 98

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107128.2 → NP_001100598.2  zinc finger protein 68 isoform 1

    See identical proteins and their annotated locations for NP_001100598.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1Z5, D3ZIP9
    Related
    ENSRNOP00000001784.5, ENSRNOT00000001784.9
    Conserved Domains (6) summary
    smart00349
    Location:10 → 70
    KRAB; krueppel associated box
    COG5048
    Location:293 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:541 → 563
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:10 → 49
    KRAB; KRAB box
    pfam13465
    Location:416 → 440
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001142945.1 → NP_001136417.1  zinc finger protein 68 isoform 2

    See identical proteins and their annotated locations for NP_001136417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1Z6
    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:255 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:503 → 525
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:378 → 402
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    21139838..21154775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768975.4 → XP_008767197.1  zinc finger protein 68 isoform X1

    See identical proteins and their annotated locations for XP_008767197.1

    UniProtKB/TrEMBL
    A6K1Z5, D3ZIP9
    Conserved Domains (6) summary
    smart00349
    Location:10 → 70
    KRAB; krueppel associated box
    COG5048
    Location:293 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:541 → 563
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:10 → 49
    KRAB; KRAB box
    pfam13465
    Location:416 → 440
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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