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Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304290, updated on 2-Nov-2024

Summary

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Official Symbol
Kdelr2provided by RGD
Official Full Name
KDEL endoplasmic reticulum protein retention receptor 2provided by RGD
Primary source
RGD:1304618
See related
AllianceGenome:RGD:1304618
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in cis-Golgi network and endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 267.4), Kidney (RPKM 226.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kdelr2 in Genome Data Viewer
Location:
12p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16252424..16270737, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11138820..11157117, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13192452..13210758, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene Rac family small GTPase 1 Neighboring gene diacylglycerol lipase, beta Neighboring gene Grid2 interacting protein Neighboring gene uncharacterized LOC134481326

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequence of a second human KDEL receptor. Lewis MJ, et al. J Mol Biol, 1992 Aug 20. PMID 1325562
  2. A molecular specificity code for the three mammalian KDEL receptors. Raykhel I, et al. J Cell Biol, 2007 Dec 17. PMID 18086916, Free PMC Article
  3. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, et al. J Neurosci, 2009 May 27. PMID 19474315, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ER retention sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables KDEL sequence binding IEA
Inferred from Electronic Annotation
more info
  
enables KDEL sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables KDEL sequence binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein localization in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein localization in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein retention in ER lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein retention in ER lumen IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in COPI-coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in COPI-coated vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ER lumen protein-retaining receptor 2
Names
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDEL receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013122.2 → NP_001013140.1  ER lumen protein-retaining receptor 2

    See identical proteins and their annotated locations for NP_001013140.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q5U305
    UniProtKB/TrEMBL
    A6K1L0
    Conserved Domains (1) summary
    pfam00810
    Location:28 → 169
    ER_lumen_recept; ER lumen protein retaining receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    16252424..16270737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271257.1 → XP_063127327.1  ER lumen protein-retaining receptor 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U305.1 GenPept UniProtKB/Swiss-Prot:Q5U305

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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