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elf1 E74-like ETS transcription factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 30396, updated on 12-Sep-2024

Summary

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Official Symbol
elf1provided by ZNC
Official Full Name
E74-like ETS transcription factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-335
See related
Ensembl:ENSDARG00000020759 AllianceGenome:ZFIN:ZDB-GENE-980526-335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ef1; zef1; fb05d07; wu:fb05d07
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in endothelial cell and periderm. Orthologous to several human genes including ELF4 (E74 like ETS transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See elf1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (40745833..40850377, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (40378579..40483114, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene protocadherin 19 Neighboring gene tenomodulin Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors. Mouriec K, et al. Biol Reprod, 2009 May. PMID 19129512
  2. D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. Ghiselli G, et al. BMC Dev Biol, 2005 Sep 12. PMID 16156897, Free PMC Article
  3. Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Liu F, et al. Circ Res, 2008 Nov 7. PMID 18832752
  4. ETS factors regulate Vegf-dependent arterial specification. Wythe JD, et al. Dev Cell, 2013 Jul 15. PMID 23830865, Free PMC Article
  5. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ETS-related transcription factor Elf-1
Names
E74-like factor 1 (ets domain transcription factor)
ETS-related factor1
etID23096.14
etID32924.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131159.2 → NP_571234.2  ETS-related transcription factor Elf-1

    Status: VALIDATED

    Source sequence(s)
    BX510995
    UniProtKB/TrEMBL
    A0A8M6Z2K0, E7F1J0
    Related
    ENSDARP00000107670.2, ENSDART00000122369.4
    Conserved Domains (2) summary
    pfam00178
    Location:203 → 282
    Ets; Ets-domain
    pfam12310
    Location:2 → 107
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    40745833..40850377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213153.1 → XP_068069254.1  ETS-related transcription factor Elf-1 isoform X2

  2. XM_017358979.3 → XP_017214468.1  ETS-related transcription factor Elf-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2K0, E7F1J0
    Conserved Domains (2) summary
    pfam00178
    Location:203 → 282
    Ets; Ets-domain
    pfam12310
    Location:2 → 107
    Elf-1_N; Transcription factor protein N terminal

  3. XM_017358978.3 → XP_017214467.1  ETS-related transcription factor Elf-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2K0, E7F1J0
    Conserved Domains (2) summary
    pfam00178
    Location:203 → 282
    Ets; Ets-domain
    pfam12310
    Location:2 → 107
    Elf-1_N; Transcription factor protein N terminal

  4. XM_017358980.3 → XP_017214469.1  ETS-related transcription factor Elf-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z202

  5. XM_068213154.1 → XP_068069255.1  ETS-related transcription factor Elf-1 isoform X3

  6. XM_017358977.3 → XP_017214466.1  ETS-related transcription factor Elf-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2K0, E7F1J0
    Conserved Domains (2) summary
    pfam00178
    Location:203 → 282
    Ets; Ets-domain
    pfam12310
    Location:2 → 107
    Elf-1_N; Transcription factor protein N terminal
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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