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B4galt4 beta-1,4-galactosyltransferase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303923, updated on 2-Nov-2024

Summary

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Official Symbol
B4galt4provided by RGD
Official Full Name
beta-1,4-galactosyltransferase 4provided by RGD
Primary source
RGD:1307880
See related
EnsemblRapid:ENSRNOG00000003114 AllianceGenome:RGD:1307880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetyllactosamine synthase activity. Predicted to be involved in glycosylation; keratan sulfate biosynthetic process; and lactosylceramide biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT4 (beta-1,4-galactosyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 111.8), Uterus (RPKM 60.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See B4galt4 in Genome Data Viewer
Location:
11q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75501358..75527291, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (61995807..62021751, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64558006..64584054, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene testis expressed 55 Neighboring gene uroplakin 1B Neighboring gene uncharacterized LOC134481005 Neighboring gene Rho GTPase activating protein 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosamine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetyllactosamine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables UDP-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-galactosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in keratan sulfate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lactosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lactosylceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 4
Names
N-acetyllactosamine synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
b4Gal-T4
beta-1,4-GalTase 4
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
beta4Gal-T4
lactotriaosylceramide beta-1,4-galactosyltransferase
nal synthase
NP_001012018.1
XP_017453489.1
XP_063126597.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012018.1 → NP_001012018.1  beta-1,4-galactosyltransferase 4

    See identical proteins and their annotated locations for NP_001012018.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081866
    UniProtKB/Swiss-Prot
    Q66HH1
    UniProtKB/TrEMBL
    A6IR55
    Related
    ENSRNOP00000004289.4, ENSRNOT00000004289.8
    Conserved Domains (1) summary
    cd00899
    Location:122 → 339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    75501358..75527291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598000.3 → XP_017453489.1  beta-1,4-galactosyltransferase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q66HH1
    UniProtKB/TrEMBL
    A6IR55
    Conserved Domains (1) summary
    cd00899
    Location:122 → 339
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. XM_063270527.1 → XP_063126597.1  beta-1,4-galactosyltransferase 4 isoform X2

RNA

  1. XR_005491030.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HH1.1 GenPept UniProtKB/Swiss-Prot:Q66HH1

Gene LinkOut

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