fzd7a frizzled class receptor 7a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd7aprovided by ZNC
Official Full Name: frizzled class receptor 7aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-223
See related: Ensembl:ENSDARG00000060004 AllianceGenome:ZFIN:ZDB-GENE-990415-223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz7; zg07; id:ibd2735; wu:fc17e10
Summary: Predicted to enable Wnt-activated receptor activity and Wnt-protein binding activity. Acts upstream of or within several processes, including chondrocyte proliferation; epiboly; and gastrulation. Located in plasma membrane. Is expressed in several structures, including margin; mesenchyme; nervous system; neural tube; and pharyngeal arch. Orthologous to human FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (13352308..13355042, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (13381105..13383834, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

uniform activation of Fz7 signaling in prechordal plate cells fully rescues defective directed cell migration in fz7 mutant embryos.
Title: Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration.
cysteine-rich domain of sFRP2 is sufficient for Ror2 activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc expression but inhibits Fz7 signaling.
Title: Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation.
frzb and fzd7a are required for extension of the palate and formation of the lower jaw.
Title: Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis.
Fz7-controlled cell division orientation has a role in neural rod midline formation during neurulation.
Title: Stereotypical cell division orientation controls neural rod midline formation in zebrafish.
fzd7a is only expressed in the neural crest of the pharyngeal arches
Title: Expression of five frizzleds during zebrafish craniofacial development.

Submit: New GeneRIF Correction

General gene information

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Markers

fc17e10.x1 (e-PCR)
- UniSTS:192833

U49411 (e-PCR)
- UniSTS:187065

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epiboly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromast development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: frizzled-7a

Names: frizzled homolog 7a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131139.2 → NP_571214.2 frizzled-7a precursor

Status: VALIDATED

Source sequence(s)

CR407547

UniProtKB/TrEMBL

Q6NV44, Q90ZT3

Related

ENSDARP00000106912.1, ENSDART00000084055.6

Conserved Domains (3) summary

cd14964
Location:238 → 262

7tm_GPCRs; TM helix 1 [structural motif]

cl02447
Location:41 → 163

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl28897
Location:228 → 558

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily