Arhgap44 Rho GTPase activating protein 44 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap44provided by RGD
Official Full Name: Rho GTPase activating protein 44provided by RGD
Primary source: RGD:1305664
See related: EnsemblRapid:ENSRNOG00000003603 AllianceGenome:RGD:1305664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RICH-2; RGD1305664
Summary: Enables GTPase activator activity. Involved in negative regulation of filopodium assembly. Located in dendrite; postsynapse; and presynapse. Is active in glutamatergic synapse; postsynaptic density; and presynaptic active zone. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 139.8), Heart (RPKM 84.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (50154724..50322027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (49655583..49822876, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (51501547..51669546, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression increases during neuronal development, concurrent with a decrease in the rate of filopodia formation.
Title: Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137170 (e-PCR)
- UniSTS:219258

RH11339 (e-PCR)
- UniSTS:87720

RH138269 (e-PCR)
- UniSTS:220356

RH131220 (e-PCR)
- UniSTS:214503

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in modification of dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
involved_in modification of dendritic spine	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in leading edge membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho GTPase-activating protein 44

Names: rho-type GTPase-activating protein RICH2; rhoGAP interacting with CIP4 homologs protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419596.1 → NP_001406525.1 rho GTPase-activating protein 44

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

F1LQX4, F1LST2, M0RAT0

Related

ENSRNOP00000096546.1, ENSRNOT00000101528.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

50154724..50322027 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269017.1 → XP_063125087.1 rho GTPase-activating protein 44 isoform X1

Related

ENSRNOP00000004829.8, ENSRNOT00000004829.10
XM_063269021.1 → XP_063125091.1 rho GTPase-activating protein 44 isoform X5
XM_063269020.1 → XP_063125090.1 rho GTPase-activating protein 44 isoform X4

Related

ENSRNOP00000066638.3, ENSRNOT00000071595.4
XM_039087288.2 → XP_038943216.1 rho GTPase-activating protein 44 isoform X2

UniProtKB/TrEMBL

A0A0H2UHC0

Conserved Domains (4) summary

PHA03247
Location:543 → 799

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:545 → 663

PRK10263; DNA translocase FtsK; Provisional

cl02570
Location:239 → 439

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:5 → 250

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_063269022.1 → XP_063125092.1 rho GTPase-activating protein 44 isoform X6
XM_063269018.1 → XP_063125088.1 rho GTPase-activating protein 44 isoform X3

Related

ENSRNOP00000103825.1, ENSRNOT00000167941.1