neurog1 neurogenin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: neurog1provided by ZNC
Official Full Name: neurogenin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-174
See related: Ensembl:ENSDARG00000056130 AllianceGenome:ZFIN:ZDB-GENE-990415-174
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ngn1; ngr1; NGN-1; cb260; zNgn1; Zath4c; neurod3; chunp6899
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in generation of neurons; hindbrain morphogenesis; and peripheral nervous system development. Acts upstream of or within several processes, including negative regulation of neurogenesis; nervous system development; and olfactory placode development. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to human NEUROG1 (neurogenin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (26703331..26704819, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (26405226..26406714, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.
Title: Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish.
Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons.
Title: Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons.
Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development.
Title: Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development.
zebrafish Dmrta2 controls neurogenin1 expression by repressing her6 in the posterior-dorsal telencephalon
Title: Zebrafish Dmrta2 regulates neurogenesis in the telencephalon.
Id3 was expressed specifically in a subset of DA neurons in the ventral diencephalon, with co-expression of neurogenin1 (Ngn1).
Title: Expression of ventral diencephalon-enriched genes in zebrafish.
an Ngn1-responsive cis-regulatory modules at the zebrafish deltaA locus that functions via the non-redundant interaction of three consensus Ngn E-boxes were identified.
Title: A cluster of non-redundant Ngn1 binding sites is required for regulation of deltaA expression in zebrafish.
Neurog1 acts as the key factor in this lineage to direct the formation of sensory neurons in zebrafisn.
Title: Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1.
identify Ngn1 as a determinant of brain dopaminergic neurons and provide insights into how forebrain embryonic zinc-finger like regulates the development of these clinically important neuronal types
Title: Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl.
Data suggest that Her5 acts as a prepattern gene to suppress both neurogenin1 (ngn1) and coe2 mRNA expression and to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate.
Title: Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of Notch to inhibit neurogenesis at the midbrain-hindbrain boundary.
neurogenin1 (ngn1) is required for the development of all zebrafish cranial ganglia
Title: Neurogenin1 defines zebrafish cranial sensory ganglia precursors.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

NGR1 (e-PCR)
- UniSTS:205377

ngn1 (e-PCR)
- UniSTS:187001

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior lateral line nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain neuron development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within forebrain neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habenula development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hindbrain morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within nervous system development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory placode development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory placode development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within posterior lateral line nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurogenin-1

Names: neurogenic differentiation 3; neurogenic differentiation factor 3; neurogenin-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131041.1 → NP_571116.1 neurogenin-1

See identical proteins and their annotated locations for NP_571116.1

Status: PROVISIONAL

Source sequence(s)

AF036149

UniProtKB/Swiss-Prot

O42606

Related

ENSDARP00000073024.3, ENSDART00000078563.5

Conserved Domains (2) summary

cd00083
Location:68 → 127

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam15794
Location:20 → 102

CCDC106; Coiled-coil domain-containing protein 106