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dlb deltaB [ Danio rerio (zebrafish) ]

Gene ID: 30141, updated on 2-Nov-2024

Summary

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Official Symbol
dlbprovided by ZNC
Official Full Name
deltaBprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-114
See related
Ensembl:ENSDARG00000004232 AllianceGenome:ZFIN:ZDB-GENE-980526-114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sc:d0400; etID309872.5
Summary
Predicted to enable Notch binding activity. Acts upstream of or within diencephalon development and midbrain development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophyseal placode; digestive system; ectoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dlb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (36693889..36701760)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36093736..36101607)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene calpain, small subunit 1 a Neighboring gene zgc:153990 Neighboring gene uncharacterized LOC103911090 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. EphrinB2a in the zebrafish retinotectal system. Wagle M, et al. J Neurobiol, 2004 Apr. PMID 15007827
  2. Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish. DeCarvalho AC, et al. Dev Dyn, 2004 Apr. PMID 15042710
  3. DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock. Wright GJ, et al. Development, 2011 Jul. PMID 21653612
  4. Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Del Bene F, et al. Cell, 2008 Sep 19. PMID 18805097, Free PMC Article
  5. The vesicular integral protein-like gene is essential for development of a mechanosensory system in zebrafish. Chong M, et al. Dev Neurobiol, 2008 Oct. PMID 18712783

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within diencephalon development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within diencephalon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
delta-like protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130958.1 → NP_571033.1  delta-like protein B precursor

    See identical proteins and their annotated locations for NP_571033.1

    Status: PROVISIONAL

    Source sequence(s)
    AF006488
    UniProtKB/Swiss-Prot
    O57409
    UniProtKB/TrEMBL
    Q1LYD2
    Related
    ENSDARP00000021660.7, ENSDART00000019259.9
    Conserved Domains (3) summary
    cd00054
    Location:311 → 346
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:141 → 203
    DSL; Delta serrate ligand
    pfam07657
    Location:21 → 75
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    36693889..36701760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O57409.1 GenPept UniProtKB/Swiss-Prot:O57409

Gene LinkOut

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