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Acsbg2 acyl-CoA synthetase bubblegum family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301120, updated on 17-Aug-2024

Summary

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Official Symbol
Acsbg2provided by RGD
Official Full Name
acyl-CoA synthetase bubblegum family member 2provided by RGD
Primary source
RGD:1588580
See related
EnsemblRapid:ENSRNOG00000045947 AllianceGenome:RGD:1588580
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable acyl-CoA hydrolase activity and arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human ACSBG2 (acyl-CoA synthetase bubblegum family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 445.7) See more
Orthologs
human mouse all
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Genomic context

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See Acsbg2 in Genome Data Viewer
Location:
9q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1770971..1802635, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1683846..1715517, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10172317..10203550)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene regulatory factor X2 Neighboring gene uncharacterized LOC120094598 Neighboring gene myosin light chain 12B, pseudogene 2 Neighboring gene acyl-CoA synthetase bubblegum family member 3 Neighboring gene MLLT1, super elongation complex subunit Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. Fraisl P, et al. Arch Biochem Biophys, 2006 Jul 1. PMID 16762313
  2. The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase. Pei Z, et al. J Biol Chem, 2006 Mar 10. PMID 16371355
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC156748

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG2
Names
arachidonate--CoA ligase ACSBG2
bubblegum-related acyl-CoA synthetase 2
NP_001073565.1
XP_006244373.1
XP_063122895.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080096.1 → NP_001073565.1  long-chain-fatty-acid--CoA ligase ACSBG2

    See identical proteins and their annotated locations for NP_001073565.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129110
    UniProtKB/Swiss-Prot
    A1L1K7
    Conserved Domains (1) summary
    cd05933
    Location:69 → 665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    1770971..1802635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244311.5 → XP_006244373.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

    See identical proteins and their annotated locations for XP_006244373.1

    UniProtKB/TrEMBL
    A6KQU4
    Related
    ENSRNOP00000066937.2, ENSRNOT00000074555.4
    Conserved Domains (2) summary
    COG1022
    Location:78 → 698
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    cl17068
    Location:100 → 696
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_063266825.1 → XP_063122895.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

    UniProtKB/TrEMBL
    A6KQU4

RNA

  1. XR_001839650.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L1K7.1 GenPept UniProtKB/Swiss-Prot:A1L1K7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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