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Scap SREBF chaperone [ Rattus norvegicus (Norway rat) ]

Gene ID: 301024, updated on 17-Aug-2024

Summary

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Official Symbol
Scapprovided by RGD
Official Full Name
SREBF chaperoneprovided by RGD
Primary source
RGD:1309378
See related
EnsemblRapid:ENSRNOG00000020853 AllianceGenome:RGD:1309378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable sterol binding activity. Involved in aging. Located in intracellular membrane-bounded organelle. Part of protein-containing complex. Orthologous to human SCAP (SREBF chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 119.6), Kidney (RPKM 101.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scap in Genome Data Viewer
Location:
8q32
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119184366..119239086)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110306026..110360677)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118551869..118628650)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S23, pseudogene 11 Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene neutrophilic granule protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. Yellaturu CR, et al. J Biol Chem, 2009 Mar 20. PMID 19158095, Free PMC Article
  2. Caloric restrictions affect some factors involved in age-related hypercholesterolemia. Martini C, et al. J Cell Biochem, 2007 May 1. PMID 17203467
  3. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Kuriyama H, et al. Cell Metab, 2005 Jan. PMID 16054043
  4. A new feature on the cholesterol-lowering landscape. Rader DJ. Nat Med, 2001 Dec. PMID 11726962
  5. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Matsuda M, et al. Genes Dev, 2001 May 15. PMID 11358865, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. insulin selectively stimulates the processing of SREBP-1c in rat hepatocytes by enhancing the association between the SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi transport and proteolytic cleavage.
    Title: Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.
  2. Caloric restriction affects SREBP involved in age-related hypercholesterolemia.
    Title: Caloric restrictions affect some factors involved in age-related hypercholesterolemia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sterol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in SREBP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in SREBP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cellular lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to insulin ISO
Inferred from Sequence Orthology
more info
  
involved_in response to vitamin B3 IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SREBP-SCAP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sterol regulatory element-binding protein cleavage-activating protein
Names
SREBP cleavage activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100966.2 → NP_001094436.1  sterol regulatory element-binding protein cleavage-activating protein

    See identical proteins and their annotated locations for NP_001094436.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    A2RRU4
    Related
    ENSRNOP00000028295.5, ENSRNOT00000028295.9
    Conserved Domains (5) summary
    smart00320
    Location:771 → 802
    WD40; WD40 repeats
    TIGR00917
    Location:11 → 466
    2A060601; Niemann-Pick C type protein family
    sd00039
    Location:1008 → 1044
    7WD40; WD40 repeat [structural motif]
    pfam12349
    Location:308 → 454
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    cl29593
    Location:1075 → 1232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119184366..119239086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265271.1 → XP_063121341.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    UniProtKB/Swiss-Prot
    A2RRU4

  2. XM_063265270.1 → XP_063121340.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    UniProtKB/Swiss-Prot
    A2RRU4

  3. XM_039081248.2 → XP_038937176.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

    UniProtKB/Swiss-Prot
    A2RRU4
    Conserved Domains (5) summary
    smart00320
    Location:771 → 802
    WD40; WD40 repeats
    TIGR00917
    Location:11 → 466
    2A060601; Niemann-Pick C type protein family
    sd00039
    Location:1008 → 1044
    7WD40; WD40 repeat [structural motif]
    pfam12349
    Location:308 → 454
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    cl29593
    Location:1075 → 1232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_017595597.3 → XP_017451086.1  sterol regulatory element-binding protein cleavage-activating protein isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RRU4.1 GenPept UniProtKB/Swiss-Prot:A2RRU4

Gene LinkOut

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