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Eef1d eukaryotic translation elongation factor 1 delta [ Rattus norvegicus (Norway rat) ]

Gene ID: 300033, updated on 2-Nov-2024

Summary

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Official Symbol
Eef1dprovided by RGD
Official Full Name
eukaryotic translation elongation factor 1 deltaprovided by RGD
Primary source
RGD:621174
See related
EnsemblRapid:ENSRNOG00000021638 AllianceGenome:RGD:621174
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum; fibrillar center; and nucleoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol and glutamatergic synapse. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 250.4), Muscle (RPKM 240.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef1d in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109462645..109478021, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107581930..107596735, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116928264..116942981, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene GDP-L-fucose synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene. Joseph P, et al. J Biol Chem, 2002 Feb 22. PMID 11711542
  2. Elongation factor 1 delta is enhanced following exposure to ionizing radiation. Jung M, et al. Cancer Res, 1994 May 15. PMID 8168075
  3. Quantitative analysis of synaptic phosphorylation and protein expression. Trinidad JC, et al. Mol Cell Proteomics, 2008 Apr. PMID 18056256
  4. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. Sanders J, et al. J Cell Sci, 1996 May. PMID 8743958
  5. Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing. Kaitsuka T, et al. EMBO Rep, 2011 Jul 1. PMID 21597468, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
elongation factor 1-delta
Names
EF-1-delta
guanine nucleotide exchange protein
translation elongation factor 1-delta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013104.1 → NP_001013122.1  elongation factor 1-delta

    See identical proteins and their annotated locations for NP_001013122.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079391
    UniProtKB/TrEMBL
    A0A8L2QI22
    Conserved Domains (1) summary
    pfam00736
    Location:567 → 650
    EF1_GNE; EF-1 guanine nucleotide exchange domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109462645..109478021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263305.1 → XP_063119375.1  elongation factor 1-delta isoform X13

  2. XM_063263302.1 → XP_063119372.1  elongation factor 1-delta isoform X13

  3. XM_063263296.1 → XP_063119366.1  elongation factor 1-delta isoform X9

  4. XM_063263303.1 → XP_063119373.1  elongation factor 1-delta isoform X13

  5. XM_063263300.1 → XP_063119370.1  elongation factor 1-delta isoform X13

  6. XM_017594765.3 → XP_017450254.1  elongation factor 1-delta isoform X14

    UniProtKB/TrEMBL
    A0A8I6GFR4, A0A8I6GJH3

  7. XM_039078815.2 → XP_038934743.1  elongation factor 1-delta isoform X16

    UniProtKB/TrEMBL
    A0A8I5ZUU1, A0A8I6GFR4, A6HS30
    Related
    ENSRNOP00000081329.1, ENSRNOT00000111979.2
    Conserved Domains (1) summary
    pfam00736
    Location:193 → 276
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  8. XM_008765561.3 → XP_008763783.1  elongation factor 1-delta isoform X17

    See identical proteins and their annotated locations for XP_008763783.1

    UniProtKB/TrEMBL
    A0A8I6AQM3, A0A8I6GFR4, A6HS29
    Conserved Domains (1) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  9. XM_008765557.3 → XP_008763779.1  elongation factor 1-delta isoform X15

    See identical proteins and their annotated locations for XP_008763779.1

    UniProtKB/Swiss-Prot
    Q68FR9
    UniProtKB/TrEMBL
    A0A8I6GFR4, A6HS33
    Conserved Domains (1) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  10. XM_008765559.3 → XP_008763781.1  elongation factor 1-delta isoform X15

    See identical proteins and their annotated locations for XP_008763781.1

    UniProtKB/Swiss-Prot
    Q68FR9
    UniProtKB/TrEMBL
    A0A8I6GFR4, A6HS33
    Conserved Domains (1) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  11. XM_039078811.2 → XP_038934739.1  elongation factor 1-delta isoform X9

    UniProtKB/TrEMBL
    A0A8L2QI22
    Conserved Domains (1) summary
    pfam00736
    Location:568 → 651
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  12. XM_063263301.1 → XP_063119371.1  elongation factor 1-delta isoform X13

  13. XM_008765551.4 → XP_008763773.1  elongation factor 1-delta isoform X7

    See identical proteins and their annotated locations for XP_008763773.1

    UniProtKB/TrEMBL
    A0A8I5ZWY7, A0A8L2QI22
    Conserved Domains (1) summary
    pfam00736
    Location:587 → 670
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  14. XM_063263283.1 → XP_063119353.1  elongation factor 1-delta isoform X2

  15. XM_063263288.1 → XP_063119358.1  elongation factor 1-delta isoform X5

  16. XM_063263282.1 → XP_063119352.1  elongation factor 1-delta isoform X1

  17. XM_063263290.1 → XP_063119360.1  elongation factor 1-delta isoform X6

  18. XM_017594767.3 → XP_017450256.1  elongation factor 1-delta isoform X14

    UniProtKB/TrEMBL
    A0A8I6GFR4, A0A8I6GJH3

  19. XM_063263287.1 → XP_063119357.1  elongation factor 1-delta isoform X4

  20. XM_063263285.1 → XP_063119355.1  elongation factor 1-delta isoform X3

  21. XM_039078818.2 → XP_038934746.1  elongation factor 1-delta isoform X17

    UniProtKB/TrEMBL
    A0A8I6AQM3, A0A8I6GFR4, A6HS29
    Conserved Domains (1) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  22. XM_039078813.2 → XP_038934741.1  elongation factor 1-delta isoform X11

    UniProtKB/TrEMBL
    A0A8L2QI22
    Conserved Domains (1) summary
    pfam00736
    Location:563 → 646
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  23. XM_039078814.2 → XP_038934742.1  elongation factor 1-delta isoform X12

    UniProtKB/TrEMBL
    A0A8L2QI22
    Related
    ENSRNOP00000096307.2, ENSRNOT00000110570.2
    Conserved Domains (1) summary
    pfam00736
    Location:544 → 627
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  24. XM_039078812.2 → XP_038934740.1  elongation factor 1-delta isoform X10

    UniProtKB/TrEMBL
    A0A8L2QI22
    Conserved Domains (1) summary
    pfam00736
    Location:567 → 650
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  25. XM_063263298.1 → XP_063119368.1  elongation factor 1-delta isoform X10

  26. XM_063263293.1 → XP_063119363.1  elongation factor 1-delta isoform X8

  27. XM_063263294.1 → XP_063119364.1  elongation factor 1-delta isoform X9

    Related
    ENSRNOP00000087171.2, ENSRNOT00000098616.2

  28. XM_063263286.1 → XP_063119356.1  elongation factor 1-delta isoform X3

  29. XM_063263291.1 → XP_063119361.1  elongation factor 1-delta isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZWY7
    Related
    ENSRNOP00000092090.2, ENSRNOT00000106771.2

  30. XM_063263281.1 → XP_063119351.1  elongation factor 1-delta isoform X1

  31. XM_063263295.1 → XP_063119365.1  elongation factor 1-delta isoform X9

  32. XM_063263299.1 → XP_063119369.1  elongation factor 1-delta isoform X10

  33. XM_063263284.1 → XP_063119354.1  elongation factor 1-delta isoform X2

  34. XM_063263292.1 → XP_063119362.1  elongation factor 1-delta isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZWY7

  35. XM_063263280.1 → XP_063119350.1  elongation factor 1-delta isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FR9.2 GenPept UniProtKB/Swiss-Prot:Q68FR9

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