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Dnaaf11 dynein axonemal assembly factor 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299920, updated on 2-Nov-2024

Summary

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Symbol
Dnaaf11provided by RGD
Full Name
dynein axonemal assembly factor 11provided by RGD
Primary source
RGD:1559937
See related
EnsemblRapid:ENSRNOG00000005233 AllianceGenome:RGD:1559937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrtp; Lrrc6; Tslrp
Summary
Predicted to be involved in cilium assembly; male gonad development; and protein localization to motile cilium. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and protein localization to cilium. Predicted to be located in cilium. Predicted to be active in apical cytoplasm and cytosol. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 19. Orthologous to human DNAAF11 (dynein axonemal assembly factor 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 198.8), Lung (RPKM 31.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Dnaaf11 in Genome Data Viewer
Location:
7q33
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100033843..100134979, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98141525..98245906, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107130402..107231507, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 3 Neighboring gene uncharacterized LOC134479740 Neighboring gene transfer RNA lysine (anticodon CUU) 10 Neighboring gene protein NYNRIN-like Neighboring gene Rab geranylgeranyltransferase subunit alpha, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and characterization of the mouse and human Lrrc6 (LRTP) orthologs.
    Title: Identification of a novel testis-specific leucine-rich protein in humans and mice.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC114437

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebrospinal fluid circulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cilium movement involved in determination of left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cilium movement involved in extracellular fluid movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to motile cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in reproductive system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein axonemal assembly factor 11
Names
leucine rich repeat containing 6 (testis)
leucine-rich testis-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025659.2 → NP_001020830.2  dynein axonemal assembly factor 11

    See identical proteins and their annotated locations for NP_001020830.2

    Status: VALIDATED

    Source sequence(s)
    BC097394
    UniProtKB/TrEMBL
    A0A0G2JUV1, A0A8I6APC6, A6HRR2
    Related
    ENSRNOP00000069241.2, ENSRNOT00000086263.3
    Conserved Domains (4) summary
    cd00116
    Location:20 → 127
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:23 → 45
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:46 → 86
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:46 → 98
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    100033843..100134979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078778.2 → XP_038934706.1  dynein axonemal assembly factor 11 isoform X2

    UniProtKB/TrEMBL
    A0A8I6APC6
    Related
    ENSRNOP00000093652.2, ENSRNOT00000093671.3
    Conserved Domains (2) summary
    sd00031
    Location:37 → 59
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:37 → 179
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_039078777.2 → XP_038934705.1  dynein axonemal assembly factor 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APC6
    Related
    ENSRNOP00000110103.1, ENSRNOT00000151770.1
    Conserved Domains (2) summary
    sd00031
    Location:37 → 59
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:37 → 179
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_063263251.1 → XP_063119321.1  dynein axonemal assembly factor 11 isoform X8

  4. XM_039078782.2 → XP_038934710.1  dynein axonemal assembly factor 11 isoform X7

  5. XM_039078780.2 → XP_038934708.1  dynein axonemal assembly factor 11 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AHZ3
    Conserved Domains (2) summary
    sd00031
    Location:37 → 59
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:37 → 179
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  6. XM_039078779.2 → XP_038934707.1  dynein axonemal assembly factor 11 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AHZ3
    Related
    ENSRNOP00000072085.3, ENSRNOT00000084875.3
    Conserved Domains (2) summary
    sd00031
    Location:37 → 59
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:37 → 179
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  7. XM_063263250.1 → XP_063119320.1  dynein axonemal assembly factor 11 isoform X6

  8. XM_039078781.2 → XP_038934709.1  dynein axonemal assembly factor 11 isoform X5

    Conserved Domains (2) summary
    sd00031
    Location:37 → 59
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:37 → 179
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

  1. XR_005486579.1 RNA Sequence

  2. XR_005486580.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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