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Dlst dihydrolipoamide S-succinyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 299201, updated on 2-Nov-2024

Summary

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Official Symbol
Dlstprovided by RGD
Official Full Name
dihydrolipoamide S-succinyltransferaseprovided by RGD
Primary source
RGD:1359615
See related
EnsemblRapid:ENSRNOG00000005061 AllianceGenome:RGD:1359615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 866.4), Kidney (RPKM 659.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dlst in Genome Data Viewer
Location:
6q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110489576..110512841)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104758511..104783296)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108936534..108961322)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene YLP motif containing 1 Neighboring gene small nucleolar RNA U13 Neighboring gene U4 spliceosomal RNA Neighboring gene prospero homeobox 2 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene placental growth factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene. Nakano K, et al. DNA Seq, 2002 Dec. PMID 12652908
  2. A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Matuda S, et al. Biochim Biophys Acta, 2010 Jan. PMID 19819302
  3. Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas. Remacha L, et al. Am J Hum Genet, 2019 Apr 4. PMID 30929736, Free PMC Article
  4. Purification and molecular cloning of succinyltransferase of the rat alpha-ketoglutarate dehydrogenase complex. Absence of a sequence motif of the putative E3 and/or E1 binding site. Nakano K, et al. J Biol Chem, 1991 Oct 5. PMID 1918017
  5. A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle. Matuda S, et al. Biochem Biophys Res Commun, 1997 Dec 8. PMID 9405249

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the DLST gene produces two different proteins with quite different functions via alternative splicing.
    Title: A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC95077

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydrolipoyllysine-residue succinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IC
Inferred by Curator
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of catalytic complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxoadipate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxoadipate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Names
2-oxoglutarate dehydrogenase complex component E2
E2
E2K
OGDC-E2
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
NP_001006982.2
XP_006240368.1
XP_008762978.1
XP_038967973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006981.2 → NP_001006982.2  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

    See identical proteins and their annotated locations for NP_001006982.2

    Status: VALIDATED

    Source sequence(s)
    BC083858, CB807447, CK355938, CK845707
    UniProtKB/Swiss-Prot
    Q01205, Q5XI35
    UniProtKB/TrEMBL
    A6JE02, G3V6P2
    Related
    ENSRNOP00000007298.4, ENSRNOT00000007298.6
    Conserved Domains (3) summary
    cd06849
    Location:72 → 144
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01347
    Location:72 → 454
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    pfam00198
    Location:239 → 452
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110489576..110512841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240306.3 → XP_006240368.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q8CJG5
    Related
    ENSRNOP00000109609.1, ENSRNOT00000142994.1
    Conserved Domains (3) summary
    cd06849
    Location:97 → 169
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01347
    Location:97 → 479
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    pfam00198
    Location:264 → 477
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

  2. XM_008764756.3 → XP_008762978.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X3

    UniProtKB/TrEMBL
    D0VYQ0
    Conserved Domains (1) summary
    pfam00198
    Location:55 → 268
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

  3. XM_039112045.2 → XP_038967973.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q01205, Q5XI35
    UniProtKB/TrEMBL
    Q8CJG5
    Conserved Domains (1) summary
    TIGR01347
    Location:25 → 407
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01205.2 GenPept UniProtKB/Swiss-Prot:Q01205

Gene LinkOut

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