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Ptgr2 prostaglandin reductase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299194, updated on 10-Oct-2024

Summary

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Official Symbol
Ptgr2provided by RGD
Official Full Name
prostaglandin reductase 2provided by RGD
Primary source
RGD:1310518
See related
EnsemblRapid:ENSRNOG00000038166 AllianceGenome:RGD:1310518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zadh1
Summary
Predicted to enable 15-oxoprostaglandin 13-oxidase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be located in cytoplasm. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 410.0), Muscle (RPKM 213.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptgr2 in Genome Data Viewer
Location:
6q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109662469..109694232)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103931367..103963113)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107999832..108031645)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103573 Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene uncharacterized LOC134479232 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene coenzyme Q6 monooxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Wu YH, et al. Structure, 2008 Nov 12. PMID 19000823
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC108784

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prostaglandin reductase 2
Names
15-oxoprostaglandin 13-reductase
PRG-2
zinc binding alcohol dehydrogenase, domain containing 1
zinc-binding alcohol dehydrogenase domain-containing protein 1
NP_001015009.1
NP_001386355.1
NP_001386362.1
XP_006240389.1
XP_006240391.1
XP_038967954.1
XP_063117803.1
XP_063117804.1
XP_063117805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015009.2 → NP_001015009.1  prostaglandin reductase 2 isoform 2

    See identical proteins and their annotated locations for NP_001015009.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q5BK81
    Related
    ENSRNOP00000054903.2, ENSRNOT00000058095.5
    Conserved Domains (2) summary
    COG2130
    Location:4 → 277
    CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl16912
    Location:1 → 275
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  2. NM_001399426.1 → NP_001386355.1  prostaglandin reductase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q5BK81
    UniProtKB/TrEMBL
    A6JDT8
    Related
    ENSRNOP00000103460.1, ENSRNOT00000122406.1
    Conserved Domains (1) summary
    cd08293
    Location:1 → 345
    PTGR2; Prostaglandin reductase

  3. NM_001399433.1 → NP_001386362.1  prostaglandin reductase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6G545
    Related
    ENSRNOP00000080851.1, ENSRNOT00000118264.2

RNA

  1. NR_174185.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  2. NR_174186.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109662469..109694232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240327.4 → XP_006240389.1  prostaglandin reductase 2 isoform X1

    See identical proteins and their annotated locations for XP_006240389.1

    UniProtKB/Swiss-Prot
    Q5BK81
    UniProtKB/TrEMBL
    A0A8L2QSN3, A6JDT8
    Conserved Domains (1) summary
    cd08293
    Location:1 → 345
    PTGR2; Prostaglandin reductase

  2. XM_063261735.1 → XP_063117805.1  prostaglandin reductase 2 isoform X3

  3. XM_039112026.2 → XP_038967954.1  prostaglandin reductase 2 isoform X4

    UniProtKB/TrEMBL
    A6JDU4
    Conserved Domains (1) summary
    cl16912
    Location:1 → 175
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  4. XM_063261733.1 → XP_063117803.1  prostaglandin reductase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5BK81
    UniProtKB/TrEMBL
    A6JDT8
    Related
    ENSRNOP00000055851.4, ENSRNOT00000059073.6

  5. XM_063261734.1 → XP_063117804.1  prostaglandin reductase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5BK81
    UniProtKB/TrEMBL
    A6JDT8

  6. XM_006240329.5 → XP_006240391.1  prostaglandin reductase 2 isoform X2

    UniProtKB/TrEMBL
    A6JDU5
    Conserved Domains (1) summary
    cl16912
    Location:1 → 290
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK81.2 GenPept UniProtKB/Swiss-Prot:Q5BK81

Gene LinkOut

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