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Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon [ Rattus norvegicus (Norway rat) ]

Gene ID: 299147, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp2r5eprovided by RGD
Official Full Name
protein phosphatase 2 regulatory subunit B', epsilonprovided by RGD
Primary source
RGD:1305657
See related
EnsemblRapid:ENSRNOG00000005045 AllianceGenome:RGD:1305657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Biomarker of transient cerebral ischemia. Orthologous to human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 82.0), Brain (RPKM 78.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp2r5e in Genome Data Viewer
Location:
6q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (99904569..100053672, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (94168846..94317872, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (98417974..98567016, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ras homolog family member J Neighboring gene glycoprotein hormone subunit beta 5 Neighboring gene uncharacterized LOC120093261 Neighboring gene uncharacterized LOC120103554 Neighboring gene WD repeat domain 89

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats. Xu H, et al. Rejuvenation Res, 2019 Dec. PMID 30712471
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106740.1 → NP_001100210.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform 2

    See identical proteins and their annotated locations for NP_001100210.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A0A0G2JTA1, A6HC79, D3ZHI9
    Related
    ENSRNOP00000006755.5, ENSRNOT00000006755.8
    Conserved Domains (2) summary
    PLN00122
    Location:321 → 397
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:55 → 397
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_001434268.1 → NP_001421197.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001434269.1 → NP_001421198.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RNA

  1. NR_197772.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    99904569..100053672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240222.4 → XP_006240284.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTA1, A0A8I5ZMG6
    Related
    ENSRNOP00000079138.1, ENSRNOT00000094518.2
    Conserved Domains (2) summary
    pfam01603
    Location:55 → 435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:2 → 67
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. XM_006240223.5 → XP_006240285.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTA1, A0A8I5ZMG6
    Conserved Domains (2) summary
    pfam01603
    Location:55 → 435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:2 → 67
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_006240224.5 → XP_006240286.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2

    UniProtKB/TrEMBL
    A0A0G2JTA1
    Related
    ENSRNOP00000099221.1, ENSRNOT00000173031.1
    Conserved Domains (2) summary
    PLN00122
    Location:335 → 411
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:31 → 411
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. XM_039112010.2 → XP_038967938.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3

    UniProtKB/TrEMBL
    A0A0G2JTA1, A0A8I6A9W8
    Related
    ENSRNOP00000089462.1, ENSRNOT00000105642.2
    Conserved Domains (1) summary
    pfam01603
    Location:23 → 403
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
Nucleotide Protein Strain
Heading Accession and Version

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