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Sav1 salvador family WW domain containing protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299116, updated on 2-Nov-2024

Summary

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Official Symbol
Sav1provided by RGD
Official Full Name
salvador family WW domain containing protein 1provided by RGD
Primary source
RGD:1307253
See related
EnsemblRapid:ENSRNOG00000005264 AllianceGenome:RGD:1307253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; protein serine/threonine kinase activator activity; and transcription regulator activator activity. Predicted to be involved in hippo signaling; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Predicted to act upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell population proliferation; and positive regulation of keratinocyte apoptotic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to human SAV1 (salvador family WW domain containing protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 256.9), Muscle (RPKM 226.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sav1 in Genome Data Viewer
Location:
6q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (94214514..94236354, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88478536..88500121, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92376470..92398678, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene atlastin GTPase 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 5 Neighboring gene ninein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human WW45 protein enhances MST1-mediated apoptosis in vivo. Luo X, et al. Int J Mol Med, 2009 Mar. PMID 19212654, Free PMC Article
  2. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Hwang E, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517604, Free PMC Article
  3. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. Callus BA, et al. FEBS J, 2006 Sep. PMID 16930133
  4. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Lu L, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080689, Free PMC Article
  5. Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. Park BH, et al. PLoS One, 2012. PMID 22292086, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator activator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of keratinocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of keratinocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of organ growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein salvador homolog 1
Names
45 kDa WW domain protein
Salvador homolog 1 protein
rWW45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097581.1 → NP_001091050.1  protein salvador homolog 1

    See identical proteins and their annotated locations for NP_001091050.1

    Status: PROVISIONAL

    Source sequence(s)
    AM261215
    UniProtKB/Swiss-Prot
    A4V8B4
    UniProtKB/TrEMBL
    A6HBY2, B1WBL9
    Related
    ENSRNOP00000007314.4, ENSRNOT00000007314.8
    Conserved Domains (1) summary
    cd00201
    Location:204 → 234
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    94214514..94236354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111991.2 → XP_038967919.1  protein salvador homolog 1 isoform X2

    UniProtKB/TrEMBL
    A6HBY2
    Conserved Domains (1) summary
    cd00201
    Location:204 → 234
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  2. XM_039111990.1 → XP_038967918.1  protein salvador homolog 1 isoform X1

    UniProtKB/TrEMBL
    A6HBY2
    Conserved Domains (1) summary
    cd00201
    Location:171 → 201
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  3. XM_063261704.1 → XP_063117774.1  protein salvador homolog 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V8B4.1 GenPept UniProtKB/Swiss-Prot:A4V8B4

Gene LinkOut

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