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STRN4 striatin 4 [ Homo sapiens (human) ]

Gene ID: 29888, updated on 14-Nov-2024

Summary

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Official Symbol
STRN4provided by HGNC
Official Full Name
striatin 4provided by HGNC
Primary source
HGNC:HGNC:15721
See related
Ensembl:ENSG00000090372 MIM:614767; AllianceGenome:HGNC:15721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIN; PPP2R6C; zinedin
Summary
Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 42.4), spleen (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

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See STRN4 in Genome Data Viewer
Location:
19q13.32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46719511..46746450, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49545101..49572026, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47222768..47249707, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47200828-47201328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47213106-47213924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14846 Neighboring gene uncharacterized LOC107987269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14847 Neighboring gene microRNA 320e Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47228602-47229146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47230777-47231320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47231865-47232408 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:47233845-47235044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10829 Neighboring gene fukutin related protein Neighboring gene Sharpr-MPRA regulatory region 2893 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:47287225-47288424 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47288509-47289110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47289111-47289712 Neighboring gene solute carrier family 1 member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47291519-47292120 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.
    Title: Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.
  2. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.
    Title: MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.
  3. Results showed that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells.
    Title: Silencing of STRN4 suppresses the malignant characteristics of cancer cells.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic susceptibility variants for chronic lymphocytic leukemia.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic structure IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
striatin-4
Names
protein phosphatase 2 regulatory subunit B'''gamma
striatin, calmodulin binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039877.2 → NP_001034966.1  striatin-4 isoform 2

    See identical proteins and their annotated locations for NP_001034966.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AB209003, AF212940, DA510367
    Consensus CDS
    CCDS42581.1
    UniProtKB/TrEMBL
    Q59GV6
    Related
    ENSP00000375777.1, ENST00000391910.7
    Conserved Domains (4) summary
    COG2319
    Location:423 → 753
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:437 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64 → 189
    Striatin; Striatin family
    sd00039
    Location:450 → 496
    7WD40; WD40 repeat [structural motif]

  2. NM_013403.3 → NP_037535.2  striatin-4 isoform 1

    See identical proteins and their annotated locations for NP_037535.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the central coding region, compared to variant 2. The resulting isoform (1) lacks an internal 7-aa segment, compared to isoform 2.
    Source sequence(s)
    AF212940, BC034604, DA510367
    Consensus CDS
    CCDS12690.1
    UniProtKB/Swiss-Prot
    A0A024R0V2, B4DQH7, F8VYA6, Q8NE53, Q9NRL3
    UniProtKB/TrEMBL
    Q59GV6
    Related
    ENSP00000263280.4, ENST00000263280.11
    Conserved Domains (4) summary
    COG2319
    Location:416 → 746
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:430 → 752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64 → 189
    Striatin; Striatin family
    sd00039
    Location:443 → 489
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46719511..46746450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723172.3 → XP_006723235.1  striatin-4 isoform X2

    UniProtKB/TrEMBL
    Q59GV6
    Conserved Domains (4) summary
    COG2319
    Location:431 → 761
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:445 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64 → 204
    Striatin; Striatin family
    sd00039
    Location:458 → 504
    7WD40; WD40 repeat [structural motif]

  2. XM_006723171.3 → XP_006723234.1  striatin-4 isoform X1

    UniProtKB/TrEMBL
    Q59GV6
    Conserved Domains (4) summary
    COG2319
    Location:438 → 768
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:452 → 774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:64 → 204
    Striatin; Striatin family
    sd00039
    Location:465 → 511
    7WD40; WD40 repeat [structural motif]

  3. XM_047438714.1 → XP_047294670.1  striatin-4 isoform X5

    UniProtKB/TrEMBL
    F5GYK2
    Related
    ENSP00000440901.1, ENST00000539396.5

  4. XM_047438713.1 → XP_047294669.1  striatin-4 isoform X4

  5. XM_047438712.1 → XP_047294668.1  striatin-4 isoform X3

  6. XM_047438715.1 → XP_047294671.1  striatin-4 isoform X6

  7. XM_011526878.2 → XP_011525180.1  striatin-4 isoform X7

    Conserved Domains (1) summary
    pfam08232
    Location:64 → 204
    Striatin; Striatin family

  8. XM_017026719.2 → XP_016882208.1  striatin-4 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49545101..49572026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320764.1 → XP_054176739.1  striatin-4 isoform X2

  2. XM_054320763.1 → XP_054176738.1  striatin-4 isoform X1

  3. XM_054320767.1 → XP_054176742.1  striatin-4 isoform X5

    UniProtKB/TrEMBL
    F5GYK2

  4. XM_054320766.1 → XP_054176741.1  striatin-4 isoform X4

  5. XM_054320765.1 → XP_054176740.1  striatin-4 isoform X3

  6. XM_054320768.1 → XP_054176743.1  striatin-4 isoform X6

  7. XM_054320769.1 → XP_054176744.1  striatin-4 isoform X7

  8. XM_054320770.1 → XP_054176745.1  striatin-4 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRL3.2 GenPept UniProtKB/Swiss-Prot:Q9NRL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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