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Kcnq4 potassium voltage-gated channel subfamily Q member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298496, updated on 14-Nov-2024

Summary

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Official Symbol
Kcnq4provided by RGD
Official Full Name
potassium voltage-gated channel subfamily Q member 4provided by RGD
Primary source
RGD:61799
See related
EnsemblRapid:ENSRNOG00000060435 AllianceGenome:RGD:61799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables potassium channel activity. Involved in negative regulation of dopaminergic synaptic transmission and potassium ion transport. Predicted to be located in basal plasma membrane. Predicted to be part of monoatomic ion channel complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2A and sensorineural hearing loss. Orthologous to human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 35.4), Lung (RPKM 11.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnq4 in Genome Data Viewer
Location:
5q36
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (139560366..139612212, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (134275145..134326992, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (139625783..139677300, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Neighboring gene uncharacterized LOC120102968 Neighboring gene uncharacterized LOC120102969 Neighboring gene nuclear transcription factor Y subunit gamma Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. Hansen HH, et al. J Pharmacol Exp Ther, 2006 Sep. PMID 16775195
  2. M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle. Hurley KM, et al. J Neurosci, 2006 Oct 4. PMID 17021181, Free PMC Article
  3. Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter. Zhong XZ, et al. J Physiol, 2010 Sep 1. PMID 20624791, Free PMC Article
  4. Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Coucke PJ, et al. Hum Mol Genet, 1999 Jul. PMID 10369879
  5. Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels. Oliver D, et al. J Neurosci, 2003 Mar 15. PMID 12657673, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that midbrain Kcnq4 expression regulates alcohol-related behaviors and provide evidence that KV7.4 channels are a critical mediator of excessive alcohol drinking.
    Title: Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents.
  2. Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered.
    Title: Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
  3. EPAC-dependent vasorelaxations occur in part via activation of Kv7 channels. This contributes to the isoproterenol-mediated relaxation in mesenteric, but not renal, arteries.
    Title: Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries.
  4. is concluded that K(V)7 channels, via nifedipine sensitive channels, have a role in the regulation of basal renal vascular tone.
    Title: K(V)7.4 channels participate in the control of rodent renal vascular resting tone.
  5. In cerebral arteries, Kv7.4 and Kv7.5 proteins exist predominantly as a functional heterotetramer, which regulates intrinsic myogenicity and vasodilation attributed to CGRP.
    Title: Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
  6. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
    Title: Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
  7. In 2 different rat and mouse models of hypertension, the functional impact of Kv7 channels was dramatically downregulated.
    Title: Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
  8. Findings show that K(V)7/KCNQ channels were functionally expressed in primary cultured OLCs and might play an important role in OPCs functioning in physiological or pathological conditions.
    Title: K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells.
  9. KCNQ4 potassium channel contributes to the regulation of myogenic control of cerebral artery diameter.
    Title: Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
  10. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers.
    Title: Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily KQT member 4
Names
KQT-like 4
potassium channel subunit alpha KvLQT4
potassium channel, voltage-gated KQT-like subfamily Q, member 4
potassium voltage-gated channel, KQT-like subfamily, member 4
voltage-gated potassium channel subunit Kv7.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419575.1 → NP_001406504.1  potassium voltage-gated channel subfamily KQT member 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K666
    Related
    ENSRNOP00000073695.1, ENSRNOT00000087445.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    139560366..139612212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111224.2 → XP_038967152.1  potassium voltage-gated channel subfamily KQT member 4 isoform X1

    Conserved Domains (2) summary
    pfam00520
    Location:98 → 330
    Ion_trans; Ion transport protein
    pfam03520
    Location:433 → 612
    KCNQ_channel; KCNQ voltage-gated potassium channel

  2. XM_008764110.4 → XP_008762332.1  potassium voltage-gated channel subfamily KQT member 4 isoform X3

    Conserved Domains (3) summary
    pfam00520
    Location:126 → 330
    Ion_trans; Ion transport protein
    pfam03520
    Location:416 → 599
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:246 → 320
    Ion_trans_2; Ion channel

  3. XM_039111225.2 → XP_038967153.1  potassium voltage-gated channel subfamily KQT member 4 isoform X2

    Related
    ENSRNOP00000107130.1, ENSRNOT00000126081.1
    Conserved Domains (2) summary
    pfam00520
    Location:98 → 330
    Ion_trans; Ion transport protein
    pfam03520
    Location:429 → 608
    KCNQ_channel; KCNQ voltage-gated potassium channel

  4. XM_008764111.4 → XP_008762333.1  potassium voltage-gated channel subfamily KQT member 4 isoform X4

    See identical proteins and their annotated locations for XP_008762333.1

    UniProtKB/TrEMBL
    A6IRZ1
    Conserved Domains (3) summary
    pfam00520
    Location:2 → 192
    Ion_trans; Ion transport protein
    pfam03520
    Location:332 → 515
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:108 → 182
    Ion_trans_2; Ion channel

  5. XM_039111226.2 → XP_038967154.1  potassium voltage-gated channel subfamily KQT member 4 isoform X5

    Conserved Domains (1) summary
    pfam00520
    Location:98 → 330
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JK96.1 GenPept UniProtKB/Swiss-Prot:Q9JK96

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