Magoh mago homolog, exon junction complex subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Magohprovided by RGD
Official Full Name: mago homolog, exon junction complex subunitprovided by RGD
Primary source: RGD:1305174
See related: EnsemblRapid:ENSRNOG00000012778 AllianceGenome:RGD:1305174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction subcomplex mago-y14. Orthologous to human MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 269.7), Spleen (RPKM 188.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (127868044..127875423)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (122639268..122646650)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (127480465..127487617)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of exon-exon junction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction subcomplex mago-y14	IEA Inferred from Electronic Annotation more info
part_of exon-exon junction subcomplex mago-y14	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mago nashi homolog

Names: mago homolog, exon junction complex core component; mago-nashi homolog, proliferation-associated; mago-nashi-like proliferation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100536.1 → NP_001094006.1 protein mago nashi homolog

See identical proteins and their annotated locations for NP_001094006.1

Status: VALIDATED

Source sequence(s)

BQ196337, CK845348, DQ359101

UniProtKB/Swiss-Prot

Q27W02

UniProtKB/TrEMBL

A6JYS9

Conserved Domains (1) summary

cd11295
Location:4 → 146

Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

127868044..127875423

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238510.5 → XP_006238572.1 protein mago nashi homolog isoform X1

UniProtKB/TrEMBL

A0A8L2Q8H0

Related

ENSRNOP00000017421.5, ENSRNOT00000017422.8

Conserved Domains (1) summary

cd11295
Location:4 → 161

Mago_nashi; Mago nashi proteins, integral members of the exon junction complex