Lag3 lymphocyte activating 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lag3provided by RGD
Official Full Name: lymphocyte activating 3provided by RGD
Primary source: RGD:1302990
See related: EnsemblRapid:ENSRNOG00000021334 AllianceGenome:RGD:1302990
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD223
Summary: Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including innate immune response; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Predicted to be active in cell surface and plasma membrane. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 486.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (159398930..159407001, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157712665..157722229, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (157425644..157433700, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting LAG-3-positive cells with cytotoxic antibodies is immunosuppressive in transplantation by depleting effectors T cells
Title: Depletion of LAG-3 positive cells in cardiac allograft reveals their role in rejection and tolerance.
LAG-3 binds to a minority of histocompatibility class II-positive cells in peripheral blood mononuclear leukocytes, including all myeloid dendritic cells, and a small fraction of monocytes.
Title: A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells.
cloning and mRNA expression; Lag3 mRNA was mainly expressed in lymphoid tissues
Title: Cloning of rat lymphocyte activation gene-3 (Lag3; CD223) cDNA and its mRNA expression in rat tissues.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class II protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of regulatory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasmacytoid dendritic cell activation	ISO Inferred from Sequence Orthology more info
involved_in plasmacytoid dendritic cell activation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lymphocyte activation gene 3 protein

Names: LAG-3; lymphocyte-activation gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212513.2 → NP_997678.2 lymphocyte activation gene 3 protein precursor

See identical proteins and their annotated locations for NP_997678.2

Status: PROVISIONAL

Source sequence(s)

BC091201

UniProtKB/Swiss-Prot

Q5BK54

UniProtKB/TrEMBL

A6ILM9, Q6XJQ1

Related

ENSRNOP00000036771.4, ENSRNOT00000028965.7

Conserved Domains (3) summary

smart00409
Location:261 → 344

IG; Immunoglobulin

pfam00047
Location:168 → 246

ig; Immunoglobulin domain

cd00096
Location:181 → 185

Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

159398930..159407001 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107451.2 → XP_038963379.1 lymphocyte activation gene 3 protein isoform X1

UniProtKB/Swiss-Prot

Q5BK54

UniProtKB/TrEMBL

A6ILM9, Q6XJQ1

Conserved Domains (3) summary

smart00409
Location:261 → 344

IG; Immunoglobulin

pfam00047
Location:168 → 246

ig; Immunoglobulin domain

cd00096
Location:181 → 185

Ig; Ig strand B [structural motif]
XM_039107452.2 → XP_038963380.1 lymphocyte activation gene 3 protein isoform X2

Conserved Domains (3) summary

smart00409
Location:261 → 344

IG; Immunoglobulin

pfam00047
Location:168 → 246

ig; Immunoglobulin domain

cd00096
Location:181 → 185

Ig; Ig strand B [structural motif]