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Ndrg3 NDRG family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296318, updated on 17-Aug-2024

Summary

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Official Symbol
Ndrg3provided by RGD
Official Full Name
NDRG family member 3provided by RGD
Primary source
RGD:1359424
See related
EnsemblRapid:ENSRNOG00000036813 AllianceGenome:RGD:1359424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Ndrg3 in Genome Data Viewer
Location:
3q42
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166007556..166070981, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145587505..145650896, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152972055..153099089, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein NDRG3-like Neighboring gene protein NDRG3-like Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene microtubule crosslinking factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3. Yang Z, et al. Mol Cell Biochem, 2021 Feb. PMID 33247804
  2. Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3. Yao Y, et al. Neurochem Res, 2017 Feb. PMID 27812761
  3. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Qu X, et al. Mol Cell Biochem, 2002 Jan. PMID 11936845
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3.
    Title: MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3.
  2. In the hypoxic response of cerebral ischemia, NDRG3 expression was found to be regulated by let-7f microRNA.
    Title: Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein NDRG3
Names
N-myc downstream regulated 3
N-myc downstream regulated gene 3
N-myc downstream regulated gene 3-like
N-myc downstream-regulated gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013923.2 → NP_001013945.1  protein NDRG3

    See identical proteins and their annotated locations for NP_001013945.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6AYR2
    UniProtKB/TrEMBL
    A0A8I6ASR6
    Related
    ENSRNOP00000086721.1, ENSRNOT00000109829.2
    Conserved Domains (2) summary
    COG0596
    Location:39 → 312
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    166007556..166070981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283384.1 → XP_063139454.1  protein NDRG3 isoform X8

    UniProtKB/TrEMBL
    A0A8I6ASR6

  2. XM_039104620.2 → XP_038960548.1  protein NDRG3 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ASR6
    Conserved Domains (1) summary
    pfam03096
    Location:20 → 305
    Ndr; Ndr family

  3. XM_063283380.1 → XP_063139450.1  protein NDRG3 isoform X3

  4. XM_063283377.1 → XP_063139447.1  protein NDRG3 isoform X1

  5. XM_039104617.2 → XP_038960545.1  protein NDRG3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ASR6, D4ACZ5
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  6. XM_063283382.1 → XP_063139452.1  protein NDRG3 isoform X6

    UniProtKB/Swiss-Prot
    Q6AYR2
    UniProtKB/TrEMBL
    A0A8I6ASR6

  7. XM_063283381.1 → XP_063139451.1  protein NDRG3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ASR6, D4ACZ5
    Related
    ENSRNOP00000052106.4, ENSRNOT00000055232.5

  8. XM_063283378.1 → XP_063139448.1  protein NDRG3 isoform X1

  9. XM_063283379.1 → XP_063139449.1  protein NDRG3 isoform X2

  10. XM_063283385.1 → XP_063139455.1  protein NDRG3 isoform X9

    UniProtKB/TrEMBL
    A0A8I6ASR6

  11. XM_063283383.1 → XP_063139453.1  protein NDRG3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ASR6

  12. XM_039104623.2 → XP_038960551.1  protein NDRG3 isoform X10

    UniProtKB/TrEMBL
    A0A8I6ASR6
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

RNA

  1. XR_010064592.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYR2.1 GenPept UniProtKB/Swiss-Prot:Q6AYR2

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials