Atp2b1 ATPase plasma membrane Ca2+ transporting 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp2b1provided by RGD
Official Full Name: ATPase plasma membrane Ca2+ transporting 1provided by RGD
Primary source: RGD:621303
See related: EnsemblRapid:ENSRNOG00000004026 AllianceGenome:RGD:621303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pmca1a; Pmca1b; Pmca1c
Summary: Enables PDZ domain binding activity. Involved in several processes, including calcium ion export; cellular response to corticosterone stimulus; and cellular response to vitamin D. Located in several cellular components, including basolateral plasma membrane; dendritic spine membrane; and neuronal cell body membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 736.4), Lung (RPKM 341.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (35622267..35731904)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (33735595..33845226)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (41114606..41223138)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Negative calcium balance in aged ovariectomized female rats is associated with downregulation of PMCA1b.
Title: Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats.
The contribution of PMCA after nerve injury in a rat model of neuropathic pain, is reported.
Title: Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons.
VDR knockdown results in a decrease in [Ca(2)]i in NRK cell lines. *
Title: Adenovirus-delivered microRNA targeting the vitamin D receptor reduces intracellular Ca²⁺ concentrations by regulating the expression of Ca²⁺-transport proteins in renal epithelial cells.
A Leu-Ile motif in 'b'-tail splice variants promotes PMCA1b and PMCA2b basolateral sorting in hair cells.
Title: Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells.
Data suggest that PMCA1a is a calcium pump specialized for neurons, where it may contribute to the modulation of somatic and dendritic Ca(2+) transients.
Title: Cellular and subcellular localization of the neuron-specific plasma membrane calcium ATPase PMCA1a in the rat brain.
Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance are reported.
Title: Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance.
PMCA isoform 1b is released via aposomes of the epithelial cells of the rat coagulating gland and that the localization of PMCA1b in the epithelial cells is influenced by androgens
Title: The localization of PMCA1b in epithelial cells and aposomes of the rat coagulating gland is influenced by androgens.
review mutagenesis work on the structure-function relationship of transmembrane segment M1 in the Na+,K+-ATPase and the sarco(endo)plasmic reticulum Ca2+-ATPase
Title: Roles of transmembrane segment M1 of Na+,K+-ATPase and Ca2-ATPase, the gatekeeper and the pivot.
PKA-mediated phosphorylation of PMCA1 differentially regulates [Ca(2+)](i) clearance in the apical region of parotid acinar cells because of a dynamic translocation of PKA
Title: Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140668 (e-PCR)
- UniSTS:222736

BF387281 (e-PCR)
- UniSTS:244276

RH144662 (e-PCR)
- UniSTS:233907

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IC Inferred by Curator more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	TAS Traceable Author Statement more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in calcium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to corticosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular associated smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor ribbon synapse	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in presynaptic active zone membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: plasma membrane calcium-transporting ATPase 1

Names: ATPase, Ca++ transporting, plasma membrane 1; PMCA1; plasma membrane calcium ATPase; plasma membrane calcium pump

NP_001386268.1

EC 7.2.2.10

NP_001386272.1

EC 7.2.2.10

NP_445763.1

EC 7.2.2.10

XP_038934528.1

EC 7.2.2.10

XP_038934529.1

EC 7.2.2.10

XP_063119193.1

EC 7.2.2.10

XP_063119194.1

EC 7.2.2.10

XP_063119195.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399339.1 → NP_001386268.1 plasma membrane calcium-transporting ATPase 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6IG75

Related

ENSRNOP00000040092.3, ENSRNOT00000041354.6

Conserved Domains (2) summary

TIGR01517
Location:15 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1103 → 1149

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001399343.1 → NP_001386272.1 plasma membrane calcium-transporting ATPase 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QSH6, A6IG74

Conserved Domains (2) summary

TIGR01517
Location:15 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1103 → 1178

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_053311.3 → NP_445763.1 plasma membrane calcium-transporting ATPase 1 isoform 3

See identical proteins and their annotated locations for NP_445763.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P11505, Q63442, Q9R1L7

UniProtKB/TrEMBL

A6IG76

Related

ENSRNOP00000059397.4, ENSRNOT00000066174.4

Conserved Domains (7) summary

TIGR01517
Location:15 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:195 → 464

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:880 → 1058

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:51 → 121

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12424
Location:1103 → 1144

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

pfam12710
Location:687 → 806

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:525 → 611

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

35622267..35731904

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263125.1 → XP_063119195.1 plasma membrane calcium-transporting ATPase 1 isoform X4
XM_039078600.2 → XP_038934528.1 plasma membrane calcium-transporting ATPase 1 isoform X1

UniProtKB/Swiss-Prot

P11505, Q63442, Q9R1L7

Conserved Domains (2) summary

TIGR01517
Location:15 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1103 → 1187

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_063263124.1 → XP_063119194.1 plasma membrane calcium-transporting ATPase 1 isoform X3

UniProtKB/TrEMBL

A6IG76
XM_039078601.2 → XP_038934529.1 plasma membrane calcium-transporting ATPase 1 isoform X1

UniProtKB/Swiss-Prot

P11505, Q63442, Q9R1L7

Conserved Domains (2) summary

TIGR01517
Location:15 → 1064

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1103 → 1187

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_063263123.1 → XP_063119193.1 plasma membrane calcium-transporting ATPase 1 isoform X2

UniProtKB/TrEMBL

A6IG75