U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vipr2 vasoactive intestinal peptide receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29555, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Vipr2provided by RGD
Official Full Name
vasoactive intestinal peptide receptor 2provided by RGD
Primary source
RGD:3962
See related
EnsemblRapid:ENSRNOG00000004317 AllianceGenome:RGD:3962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables vasoactive intestinal polypeptide receptor activity. Involved in activation of adenylate cyclase activity and negative regulation of smooth muscle cell proliferation. Predicted to be active in plasma membrane. Orthologous to human VIPR2 (vasoactive intestinal peptide receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 29.3), Thymus (RPKM 27.1) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Vipr2 in Genome Data Viewer
Location:
6q33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143139672..143213609)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (136996664..137070599)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (143932960..144009476)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Ig heavy chain V region 3-like Neighboring gene zinc finger protein 386 (Kruppel-like) Neighboring gene chromatin target of PRMT1, pseudogene 1 Neighboring gene uncharacterized LOC134479489

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions. Usdin TB, et al. Endocrinology, 1994 Dec. PMID 7988457
  2. The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide. Lutz EM, et al. FEBS Lett, 1993 Nov 8. PMID 8224221
  3. VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide in primary rat adipocytes. Akesson L, et al. Endocrinology, 2005 Feb. PMID 15514088
  4. Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia. Garry EM, et al. Mol Cell Neurosci, 2005 Dec. PMID 16202621
  5. VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus. Cunha-Reis D, et al. Ann N Y Acad Sci, 2006 Jul. PMID 16888168

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic beta cells.
    Title: VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells.
  2. PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
    Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
  3. the protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with repetitive applications of chemical dural stimulations.
    Title: Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats.
  4. In cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional; VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation.
    Title: Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.
  5. Although cerebellar arteries expressed transcripts for all three PACAP receptor subtypes, middle meningeal arteries demonstrated only PAC1 and VPAC2 receptor expression.
    Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) potently dilates middle meningeal arteries: implications for migraine.
  6. both VPAC1 and VPAC2 could have roles at all stages of retinal development, that PACAP acts through a specific set of PAC1 isoforms, and that Hip and Hop1 are predominantly involved in the postnatal development of rat retina.
    Title: Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina.
  7. Expression and distribution of vasoactive intestinal peptide receptor 2 remains unchanged in aged rat brains.
    Title: Region-specific changes in the immunoreactivity of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC2, and PAC1 receptor) in the aged rat brains.
  8. investigation of role of VPAC2 (& VPAC1) in pulmonary circulation in health/disease: distribution of VPAC2 (& VPAC1) in aorta/pulmonary artery (& smooth muscle cells); effects of VPAC antagonists on cell proliferation; dominant role of VPAC2
    Title: Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation.
  9. Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
    Title: Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
  10. inhibitory effect of pituitary adenylate cyclase-activating polypeptide on food intake may be mediated, at least in part, through modulation of neuropeptide Y neurotransmission
    Title: Expression of PACAP receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vasoactive intestinal polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vasoactive intestinal polypeptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
vasoactive intestinal polypeptide receptor 2
Names
PACAP type III receptor
PACAP-R-3
PACAP-R3
VIP-R-2
pituitary adenylate cyclase-activating polypeptide type III receptor
vasopressive intestinal peptide receptor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017238.2 → NP_058934.2  vasoactive intestinal polypeptide receptor 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P35000
    UniProtKB/TrEMBL
    A6KDK7
    Related
    ENSRNOP00000005876.5, ENSRNOT00000005876.6
    Conserved Domains (2) summary
    smart00008
    Location:47 → 117
    HormR; Domain present in hormone receptors
    cd15986
    Location:122 → 390
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    143139672..143213609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594055.3 → XP_017449544.1  vasoactive intestinal polypeptide receptor 2 isoform X1

  2. XM_063261586.1 → XP_063117656.1  vasoactive intestinal polypeptide receptor 2 isoform X1

  3. XM_039111853.2 → XP_038967781.1  vasoactive intestinal polypeptide receptor 2 isoform X5

    Conserved Domains (1) summary
    smart00008
    Location:47 → 117
    HormR; Domain present in hormone receptors

  4. XM_039111850.2 → XP_038967778.1  vasoactive intestinal polypeptide receptor 2 isoform X2

    Conserved Domains (3) summary
    smart00008
    Location:47 → 117
    HormR; Domain present in hormone receptors
    cd14964
    Location:276 → 303
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:247 → 345
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_039111852.2 → XP_038967780.1  vasoactive intestinal polypeptide receptor 2 isoform X4

    Conserved Domains (1) summary
    smart00008
    Location:47 → 117
    HormR; Domain present in hormone receptors

  6. XM_039111851.2 → XP_038967779.1  vasoactive intestinal polypeptide receptor 2 isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:20 → 42
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:13 → 252
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_005505447.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35000.1 GenPept UniProtKB/Swiss-Prot:P35000

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous